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    Memo1 mediator of cell motility 1 [ Mus musculus (house mouse) ]

    Gene ID: 76890, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Memo1provided by MGI
    Official Full Name
    mediator of cell motility 1provided by MGI
    Primary source
    MGI:MGI:1924140
    See related
    Ensembl:ENSMUSG00000058704 AllianceGenome:MGI:1924140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610016J10Rik; D930048L02Rik
    Summary
    Predicted to enable peptide binding activity. Predicted to be involved in regulation of microtubule-based process. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MEMO1 (mediator of cell motility 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.5), liver E14 (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E2; 17 45.63 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74493759..74602677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74186764..74295682, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31235 Neighboring gene STARR-seq mESC enhancer starr_43207 Neighboring gene STARR-seq mESC enhancer starr_43208 Neighboring gene STARR-positive B cell enhancer ABC_E9171 Neighboring gene predicted gene, 53978 Neighboring gene F-box protein 34 pseudogene Neighboring gene predicted gene, 52299 Neighboring gene STARR-seq mESC enhancer starr_43214 Neighboring gene STARR-seq mESC enhancer starr_43216 Neighboring gene dpy-30, histone methyltransferase complex regulatory subunit Neighboring gene predicted gene, 31328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGFR regulator Memo1 is dispensable for FGF23 expression by osteoblasts during folic acid-driven kidney injury. Bartos K, et al. Physiol Rep, 2023 Mar. PMID 36967231, Free PMC Article
    2. Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice. Moor MB, et al. PLoS One, 2020. PMID 32706793, Free PMC Article
    3. Memo1 gene expression in kidney and bone is unaffected by dietary mineral load and calciotropic hormones. Moor MB, et al. Physiol Rep, 2020 Apr. PMID 32291966, Free PMC Article
    4. Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters. Moor MB, et al. Front Physiol, 2018. PMID 30038585, Free PMC Article
    5. Loss of Memo, a novel FGFR regulator, results in reduced lifespan. Haenzi B, et al. FASEB J, 2014 Jan. PMID 24056085

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFR regulator Memo1 is dispensable for FGF23 expression by osteoblasts during folic acid-driven kidney injury.
      Title: FGFR regulator Memo1 is dispensable for FGF23 expression by osteoblasts during folic acid-driven kidney injury.
    2. Memo1 gene expression in kidney and bone is unaffected by dietary mineral load and calciotropic hormones.
      Title: Memo1 gene expression in kidney and bone is unaffected by dietary mineral load and calciotropic hormones.
    3. Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice.
      Title: Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice.
    4. Memo1 is a mediator of radial glial cell scaffold tiling, necessary to generate and organize neurons into functional ensembles in the developing cerebral cortex.
      Title: Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
    5. Memo1 showed robust expression in the perichondrium and periosteum of the developing cranial base, but only modest expression in the palatal shelves. Neural crest cell-specific deletion of Memo1 caused a failure of anterior cranial base ossification indicating a cell autonomous role for MEMO1 in the development of these structures, but palatal formation was normal, indicating a non-autonomous role in palatal closure.
      Title: MEMO1 drives cranial endochondral ossification and palatogenesis.
    6. our results show that Memo has a novel role in the S1P pathway and that Memo is needed to promote cell-autonomous S1PR activation.
      Title: Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.
    7. tissue distribution of Memo in mice.
      Title: [Preparation of antibody against Memo protein and analysis of expression profile of Memo in mouse tissues].
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MEMO1
    Names
    mediator of ErbB2-driven cell motility 1
    memo-1
    protein memo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133771.2 → NP_598532.1  protein MEMO1

      See identical proteins and their annotated locations for NP_598532.1

      Status: VALIDATED

      Source sequence(s)
      AF363447, BF466279, CT010445
      Consensus CDS
      CCDS28969.1
      UniProtKB/Swiss-Prot
      Q91VH6
      UniProtKB/TrEMBL
      Q3TWT2
      Related
      ENSMUSP00000156607.2, ENSMUST00000233514.3
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      74493759..74602677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525109.5 → XP_006525172.1  protein MEMO1 isoform X1

      See identical proteins and their annotated locations for XP_006525172.1

      UniProtKB/Swiss-Prot
      Q91VH6
      UniProtKB/TrEMBL
      Q3TWT2
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    2. XM_036160831.1 → XP_036016724.1  protein MEMO1 isoform X2

      UniProtKB/TrEMBL
      A0A3B2W7C9
      Related
      ENSMUSP00000156437.2, ENSMUST00000232989.2
      Conserved Domains (1) summary
      cd07361
      Location:9 → 219
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    3. XM_011246713.4 → XP_011245015.1  protein MEMO1 isoform X3

      See identical proteins and their annotated locations for XP_011245015.1

      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    RNA

    1. XR_003952211.2 RNA Sequence

    2. XR_385387.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VH6.1 GenPept UniProtKB/Swiss-Prot:Q91VH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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