Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gria3provided by MGI
Official Full Name: glutamate receptor, ionotropic, AMPA3 (alpha 3)provided by MGI
Primary source: MGI:MGI:95810
See related: Ensembl:ENSMUSG00000001986 AllianceGenome:MGI:95810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluA3; Glur3; GluR-C; Glur-3; GluR-K3; Gluralpha3; 2900064I19Rik
Summary: This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression: Biased expression in frontal lobe adult (RPKM 31.4), cortex adult (RPKM 28.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A4; X 23.19 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (40489351..40767478)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (41400819..41678601)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition.
Title: Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition.
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Title: Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
The central distribution of AMPARs is absent in GluA3-knockout mice, and gold particles are evenly distributed along the postsynaptic density. GluA4 gold labeling was homogenously distributed along both synapse types. Thus, GluA3 and GluA4 subunits are distributed at auditory nerve synapses in a target-cell-dependent manner.
Title: The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.
The experiments reveal a novel type of plasticity at CA1 hippocampal synapses that is expressed by the activation of GluA3-containing AMPARs.
Title: Synaptic plasticity through activation of GluA3-containing AMPA-receptors.
Results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans.
Title: A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
GluA3 is required for normal auditory signaling, normal ultrastructure of AN-BC synapses in the cochlear nucleus and normal experience-dependent changes in auditory processing after transient sound reduction.
Title: Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.
These experiments indicate that the presence of GluA3-containing AMPARs is critical for Abeta-mediated synaptic and cognitive deficits.
Title: Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3.
Cerebellar learning depends on expression of GluA3 in Purkinje cells. GluA3 is required to induce long term potentiation (LTP), but not long term depression, at parallel fiber-Purkinje cell synapses. GluA3-dependent potentiation involves a cAMP-driven change in channel conductance. GluA3-mediated LTP and learning are induced via cAMP-mediated Epac activation.
Title: Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.
These results provide direct evidence for cortical AMPA receptors to contribute to zymosan-induced visceral and spontaneous pain.
Title: Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.
Data indicate that the AMPA receptor subunits abundance is hippocampus, GluA2 > GluA1 > GluA3 >> GluA4; cortex, GluA2 > GluA3 >/= GluA1 >> GluA4; and cerebellum, GluA2 > GluA3 >/= GluA1 > GluA4.
Title: Interaction proteomics reveals brain region-specific AMPA receptor complexes.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXMit58 (e-PCR), detects polymorphism
- UniSTS:132163

Gria3 (e-PCR), detects polymorphism
- UniSTS:496045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMPA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor 3

Names: AMPA-selective glutamate receptor 3; glutamate receptor channel alpha3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281929.2 → NP_001268858.2 glutamate receptor 3 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode isoform a.

Source sequence(s)

AL672232, AL672290

Consensus CDS

CCDS30097.1

UniProtKB/Swiss-Prot

A2VDF4, Q5DTJ0, Q9Z2W9

UniProtKB/TrEMBL

Q0VGS8

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
NM_001290451.3 → NP_001277380.2 glutamate receptor 3 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains an alternate exon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is the same length but has a different sequence than isoform a.

Source sequence(s)

AL672232, AL672290

Consensus CDS

CCDS72370.1

UniProtKB/TrEMBL

B0QZW1, C9K0Y5

Related

ENSMUSP00000131523.2, ENSMUST00000165288.2

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
NM_001358361.2 → NP_001345290.2 glutamate receptor 3 isoform a precursor

Status: REVIEWED

Source sequence(s)

AL672232, AL672290

Consensus CDS

CCDS30097.1

UniProtKB/Swiss-Prot

A2VDF4, Q5DTJ0, Q9Z2W9

UniProtKB/TrEMBL

Q0VGS8

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
NM_016886.5 → NP_058582.4 glutamate receptor 3 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode isoform a.

Source sequence(s)

AL672232, AL672290

Consensus CDS

CCDS30097.1

UniProtKB/Swiss-Prot

A2VDF4, Q5DTJ0, Q9Z2W9

UniProtKB/TrEMBL

Q0VGS8

Related

ENSMUSP00000075687.6, ENSMUST00000076349.12

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

RNA

NR_104053.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL672232, AL672290

Related

ENSMUST00000139965.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

40489351..40767478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318545.3 → XP_017174034.1 glutamate receptor 3 isoform X1

UniProtKB/Swiss-Prot

A2VDF4, Q5DTJ0, Q9Z2W9

UniProtKB/TrEMBL

Q0VGS8

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
XM_017318547.3 → XP_017174036.1 glutamate receptor 3 isoform X3

UniProtKB/TrEMBL

Q3TTV2

Conserved Domains (2) summary

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

cl21456
Location:416 → 687

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_017318546.1 → XP_017174035.1 glutamate receptor 3 isoform X2

UniProtKB/TrEMBL

B0QZW1, C9K0Y5

Related

ENSMUSP00000110755.3, ENSMUST00000115103.9

Conserved Domains (2) summary

cd13715
Location:416 → 799

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06387
Location:29 → 403

PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor