Syt1 synaptotagmin I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt1provided by MGI
Official Full Name: synaptotagmin Iprovided by MGI
Primary source: MGI:MGI:99667
See related: Ensembl:ENSMUSG00000035864 AllianceGenome:MGI:99667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SytI; G630098F17Rik
Summary: Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including glutamatergic synapse; presynaptic membrane; and secretory vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 49.2), frontal lobe adult (RPKM 47.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 56.52 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (108333511..108846852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (108497650..109010980, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.
Title: Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.
Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.
Title: Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.
Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.
Title: Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.
Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.
Title: Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.
Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.
Title: Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.
Synaptotagmin-1 is a Ca[2+] sensor for somatodendritic dopamine release.
Title: Synaptotagmin-1 is a Ca(2+) sensor for somatodendritic dopamine release.
Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.
Title: Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.
Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Title: Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis.
Title: Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis.
Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release.
Title: Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Syt1 (e-PCR), detects polymorphism
- UniSTS:546590

NoName (e-PCR)
- UniSTS:492877

RH94645 (e-PCR)
- UniSTS:119892

RH78549 (e-PCR)
- UniSTS:63327

Syt1 (e-PCR), detects polymorphism
- UniSTS:507257

AW124717 (e-PCR)
- UniSTS:180117

Syt1 (e-PCR), detects polymorphism
- UniSTS:498326

D37792 (e-PCR)
- UniSTS:124827

RH140034 (e-PCR)
- UniSTS:222116

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-3 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter	IDA Inferred from Direct Assay more info	PubMed
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of regulated secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spontaneous neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synchronous neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	TAS Traceable Author Statement more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptotagmin-1

Names: p65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252341.1 → NP_001239270.1 synaptotagmin-1 isoform 1

See identical proteins and their annotated locations for NP_001239270.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.

Source sequence(s)

AI842617, AK078790, BC042519, BY268027, CD774438

Consensus CDS

CCDS24163.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Related

ENSMUSP00000100912.2, ENSMUST00000105276.8

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001252342.1 → NP_001239271.1 synaptotagmin-1 isoform 2

See identical proteins and their annotated locations for NP_001239271.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a difference splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AI842617, AK018163, AK133578, BC042519, BY268027, CD774438

UniProtKB/TrEMBL

Q3TPT3

Conserved Domains (2) summary

cd08385
Location:139 → 261

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:270 → 405

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001358501.1 → NP_001345430.1 synaptotagmin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AI842617, AK018163, AK133578, BC042519, BY259903, CD774438

UniProtKB/TrEMBL

Q3TPT3

Conserved Domains (2) summary

cd08385
Location:139 → 261

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:270 → 405

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001358502.1 → NP_001345431.1 synaptotagmin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC122472, AI842617, AK018163, BC042519, BY259903, CD774438, EL605393

Consensus CDS

CCDS24163.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001358503.1 → NP_001345432.1 synaptotagmin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AI842617, AK018163, BC042519, BY259903, CD774438, EL605393

Consensus CDS

CCDS24163.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001358504.1 → NP_001345433.1 synaptotagmin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, BY268027, CD774438

UniProtKB/TrEMBL

Q3TPT3

Conserved Domains (2) summary

cd08385
Location:139 → 261

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:270 → 405

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_001358506.1 → NP_001345435.1 synaptotagmin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, CD774438

UniProtKB/TrEMBL

Q3TPT3

Conserved Domains (2) summary

cd08385
Location:139 → 261

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:270 → 405

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_009306.3 → NP_033332.1 synaptotagmin-1 isoform 1

See identical proteins and their annotated locations for NP_033332.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AI842617, BC042519, BY238701, BY268027, CD774438

Consensus CDS

CCDS24163.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Related

ENSMUSP00000063293.8, ENSMUST00000064054.14

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

108333511..108846852 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244984.2 → XP_030100844.1 synaptotagmin-1 isoform X1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
XM_030244985.2 → XP_030100845.1 synaptotagmin-1 isoform X1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
XM_030244986.2 → XP_030100846.1 synaptotagmin-1 isoform X1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
XM_006513448.1 → XP_006513511.1 synaptotagmin-1 isoform X1

See identical proteins and their annotated locations for XP_006513511.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
XM_006513447.2 → XP_006513510.1 synaptotagmin-1 isoform X1

See identical proteins and their annotated locations for XP_006513510.1

UniProtKB/Swiss-Prot

P46096

UniProtKB/TrEMBL

H6RXZ1, Q3TPT3

Conserved Domains (2) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:273 → 408

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1