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    Slc5a4b solute carrier family 5 (neutral amino acid transporters, system A), member 4b [ Mus musculus (house mouse) ]

    Gene ID: 64454, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc5a4bprovided by MGI
    Official Full Name
    solute carrier family 5 (neutral amino acid transporters, system A), member 4bprovided by MGI
    Primary source
    MGI:MGI:1890478
    See related
    Ensembl:ENSMUSG00000020226 AllianceGenome:MGI:1890478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAAT1; SGLT3b; pSGLT2; SGLT3-b; 2010104G07Rik
    Summary
    Enables carbohydrate:cation symporter activity. Acts upstream of or within glucose transmembrane transport and sodium ion transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC5A4 (solute carrier family 5 member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 17.7), small intestine adult (RPKM 14.0) and 3 other tissues See more
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    Genomic context

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    Location:
    10 C1; 10 38.68 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75894452..75946852, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76058618..76111018, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5134 Neighboring gene STARR-positive B cell enhancer ABC_E8345 Neighboring gene STARR-seq mESC enhancer starr_27168 Neighboring gene microRNA 6409 Neighboring gene STARR-seq mESC enhancer starr_27169 Neighboring gene STARR-positive B cell enhancer ABC_E3892 Neighboring gene STARR-seq mESC enhancer starr_27170 Neighboring gene STARR-seq mESC enhancer starr_27172 Neighboring gene zinc finger protein 280B Neighboring gene predicted gene 16222 Neighboring gene STARR-seq mESC enhancer starr_27174 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b pseudogene Neighboring gene solute carrier family 5, member 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage. Yamazaki Y, et al. Neuroscience, 2014 Jun 6. PMID 24699226
    2. Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B. Díez-Sampedro A, et al. J Biol Chem, 2011 Mar 11. PMID 21187287, Free PMC Article
    3. Functional characterization of mouse sodium/glucose transporter type 3b. Aljure O, et al. Am J Physiol Cell Physiol, 2010 Jul. PMID 20392930
    4. Mouse kidney expresses mRNA of four highly related sodium-glucose cotransporters: regulation by cadmium. Tabatabai NM, et al. Kidney Int, 2003 Oct. PMID 12969150
    5. Mouse SGLT3a generates proton-activated currents but does not transport sugar. Barcelona S, et al. Am J Physiol Cell Physiol, 2012 Apr 15. PMID 22301059

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that activation of SGLT-3 in post-ischemic hyperglycemia may suppress the development of cerebral ischemic neuronal damage by releasing acetylcholine via its activation of cholinergic neurons
      Title: Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage.
    2. Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B.
      Title: Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B.
    3. Low sugar affinity and uncoupled sugar transport lead us to conclude that mSGLT3b likely functions as a physiological glucose sensor similar to hSGLT3.
      Title: Functional characterization of mouse sodium/glucose transporter type 3b.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-affinity glucose:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 5 member 4B
    Names
    low affinity sodium-glucose cotransporter
    solute carrier family 5 member 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023219.2 → NP_075708.2  solute carrier family 5 member 4B

      See identical proteins and their annotated locations for NP_075708.2

      Status: VALIDATED

      Source sequence(s)
      AC140851, AV259402, BC109133
      Consensus CDS
      CCDS48603.1
      UniProtKB/Swiss-Prot
      Q91ZP4, Q9ET36
      UniProtKB/TrEMBL
      Q3UNC8
      Related
      ENSMUSP00000113582.2, ENSMUST00000120757.2
      Conserved Domains (1) summary
      cl00456
      Location:27 → 660
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75894452..75946852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243522.1 → XP_011241824.1  solute carrier family 5 member 4B isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:13 → 511
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_017314051.1 → XP_017169540.1  solute carrier family 5 member 4B isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:1 → 450
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006513945.2 → XP_006514008.1  solute carrier family 5 member 4B isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:22 → 520
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZP4.2 GenPept UniProtKB/Swiss-Prot:Q91ZP4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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