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    Bzw2 basic leucine zipper and W2 domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 66912, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Bzw2provided by MGI
    Official Full Name
    basic leucine zipper and W2 domains 2provided by MGI
    Primary source
    MGI:MGI:1914162
    See related
    Ensembl:ENSMUSG00000020547 AllianceGenome:MGI:1914162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5mp1; Bdm2; HSPC028; 1110001I24Rik
    Summary
    Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; cardiovascular system; and genitourinary system. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 47.3), CNS E14 (RPKM 41.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A3; 12 16.42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (36141834..36206922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (36091835..36156841, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10744 Neighboring gene STARR-positive B cell enhancer ABC_E2382 Neighboring gene STARR-seq mESC enhancer starr_31914 Neighboring gene ubiquitin-conjugating enzyme E2F (putative), retrotransposed Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_31915 Neighboring gene STARR-positive B cell enhancer ABC_E1153 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene leucine rich repeat containing 72 Neighboring gene STARR-seq mESC enhancer starr_31916 Neighboring gene predicted gene, 40390

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Zhang J, et al. Nat Commun, 2022 Nov 4. PMID 36333315, Free PMC Article
    2. Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration. Shen ZJ, et al. Cells, 2021 Jan 21. PMID 33494375, Free PMC Article
    3. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
    4. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048
    5. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
      Title: BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
    2. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7203

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eIF5-mimic protein 1
    Names
    basic leucine zipper and W2 domain-containing protein 2
    brain development-related molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025840.3 → NP_080116.2  eIF5-mimic protein 1

      See identical proteins and their annotated locations for NP_080116.2

      Status: VALIDATED

      Source sequence(s)
      AK160544, BQ032572, BY009345
      Consensus CDS
      CCDS25884.1
      UniProtKB/Swiss-Prot
      Q2L4X1, Q91VK1, Q9D0N4
      UniProtKB/TrEMBL
      Q3V199
      Related
      ENSMUSP00000020856.5, ENSMUST00000020856.6
      Conserved Domains (1) summary
      cd11560
      Location:218 → 408
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      36141834..36206922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515166.4 → XP_006515229.1  eIF5-mimic protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3V199
      Related
      ENSMUST00000221521.2
      Conserved Domains (1) summary
      cl17013
      Location:218 → 369
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2L4X1.1 GenPept UniProtKB/Swiss-Prot:Q2L4X1
    Q91VK1.1 GenPept UniProtKB/Swiss-Prot:Q91VK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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