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    Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type [ Mus musculus (house mouse) ]

    Gene ID: 72077, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gcnt3provided by MGI
    Official Full Name
    glucosaminyl (N-acetyl) transferase 3, mucin typeprovided by MGI
    Primary source
    MGI:MGI:1919327
    See related
    Ensembl:ENSMUSG00000032226 AllianceGenome:MGI:1919327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010013H22Rik; 2210021I22Rik; 2210401J11Rik
    Summary
    Enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Acts upstream of or within intestinal absorption; kidney morphogenesis; and tissue morphogenesis. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Orthologous to human GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 13.8), stomach adult (RPKM 9.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 D; 9 39.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69938777..69947172, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70031495..70039890, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6762 Neighboring gene BCL2/adenovirus E1B interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_24528 Neighboring gene general transcription factor II A, 2 Neighboring gene STARR-seq mESC enhancer starr_24529 Neighboring gene STARR-seq mESC enhancer starr_24532 Neighboring gene STARR-seq mESC enhancer starr_24534 Neighboring gene predicted gene, 39369 Neighboring gene family with sequence similarity 81, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase. Hashimoto M, et al. Glycobiology, 2007 Sep. PMID 17591617
    2. Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer. Rao CV, et al. Cancer Res, 2016 Apr 1. PMID 26880801
    3. High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Ismail MN, et al. Glycobiology, 2011 Jan. PMID 20855471, Free PMC Article
    4. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. Kidder D, et al. J Immunol, 2013 Mar 15. PMID 23408841, Free PMC Article
    5. Requirement for core 2 O-glycans for optimal resistance to helminth infection. Mullaly SC, et al. PLoS One, 2013. PMID 23555902, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immunoglobulin production in mucosal tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
    Names
    C2GnT-M
    C2GnT-mucin type
    core 2 beta-1,6-N-acetylglucosaminyltransferase II
    mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
    NP_082363.2
    XP_006511526.1
    XP_011241117.1
    XP_011241118.1
    XP_030100480.1
    XP_030100481.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028087.2 → NP_082363.2  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

      See identical proteins and their annotated locations for NP_082363.2

      Status: PROVISIONAL

      Source sequence(s)
      EF202835
      Consensus CDS
      CCDS40678.1
      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Related
      ENSMUSP00000034751.6, ENSMUST00000034751.6
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      69938777..69947172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242816.3 → XP_011241118.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011241118.1

      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    2. XM_030244620.1 → XP_030100480.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    3. XM_011242815.3 → XP_011241117.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011241117.1

      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    4. XM_006511463.4 → XP_006511526.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006511526.1

      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme

    5. XM_030244621.1 → XP_030100481.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

      UniProtKB/Swiss-Prot
      A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
      Conserved Domains (1) summary
      pfam02485
      Location:133 → 400
      Branch; Core-2/I-Branching enzyme
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JCT0.2 GenPept UniProtKB/Swiss-Prot:Q5JCT0

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