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    Crtac1 cartilage acidic protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 72832, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Crtac1provided by MGI
    Official Full Name
    cartilage acidic protein 1provided by MGI
    Primary source
    MGI:MGI:1920082
    See related
    Ensembl:ENSMUSG00000042401 AllianceGenome:MGI:1920082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lotus; Crtac1B; 2810454P21Rik
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within axonal fasciculation; negative regulation of receptor binding activity; and olfactory bulb development. Located in growth cone. Is expressed in central nervous system; dorsal root ganglion; tooth; and vibrissa. Orthologous to human CRTAC1 (cartilage acidic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 14.7), cortex adult (RPKM 11.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 36.07 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42271474..42421405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42283035..42432966, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene golgin A7B Neighboring gene STARR-seq mESC enhancer starr_46179 Neighboring gene predicted gene, 34347 Neighboring gene microRNA 3085 Neighboring gene STARR-seq mESC enhancer starr_46182 Neighboring gene STARR-seq mESC enhancer starr_46183 Neighboring gene STARR-seq mESC enhancer starr_46184 Neighboring gene predicted gene, 41848 Neighboring gene STARR-seq mESC enhancer starr_46185 Neighboring gene predicted gene, 34299 Neighboring gene predicted gene, 41849 Neighboring gene predicted gene, 41850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. Ito S, et al. Stem Cell Reports, 2021 Nov 9. PMID 34653401, Free PMC Article
    2. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation. Nishida R, et al. Sci Rep, 2021 Mar 3. PMID 33658590, Free PMC Article
    3. The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans. Kawakami Y, et al. Neurosci Lett, 2018 Sep 14. PMID 29953923
    4. The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor. Kawakami Y, et al. J Neurosci, 2018 Mar 7. PMID 29440387, Free PMC Article
    5. Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS. Kurihara Y, et al. Neuroscience, 2017 Jul 25. PMID 28571719

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LOTUS suppresses amyloid beta-induced dendritic spine elimination through the blockade of amyloid beta binding to PirB.
      Title: LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.
    2. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury.
      Title: LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury.
    3. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
      Title: LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
    4. The neuronal overexpression of LOTUS in transgenic mice promotes motor recovery after spinal cord injury, and recombinant viral overexpression of LOTUS enhances retinal ganglion cell axonal regeneration after optic nerve crush. Thus, the level of LOTUS function titrates axonal regeneration.
      Title: Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.
    5. Genetic deletion of Crtac1 significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM) surgery.
      Title: Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1.
    6. These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 when bound by all four known NgR1 ligands.
      Title: LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.
    7. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1.
      Title: The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1.
    8. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest endogenous antagonism of NgR1 by LOTUS crucial for LOT formation
      Title: Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonal fasciculation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cartilage acidic protein 1
    Names
    68 kDa chondrocyte-expressed protein
    ASPIC
    CEP-68
    protein CRTAC1-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356588.1 → NP_001343517.1  cartilage acidic protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC119236, AC144792, AL603804
      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (3) summary
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:554 → 600
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    2. NM_001356589.1 → NP_001343518.1  cartilage acidic protein 1 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1
      Source sequence(s)
      AK032328, AK083221, AK149020, AK149069
      UniProtKB/TrEMBL
      A0A571BE99
      Related
      ENSMUSP00000158623.2, ENSMUST00000238290.2
      Conserved Domains (3) summary
      pfam07593
      Location:461 → 513
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:560 → 606
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    3. NM_145123.5 → NP_660105.3  cartilage acidic protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660105.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1)
      Source sequence(s)
      AK032328, AK149020, AK149069
      Consensus CDS
      CCDS29828.1
      UniProtKB/Swiss-Prot
      Q3UF32, Q3UF40, Q8BMF1, Q8R3V8, Q8R555
      UniProtKB/TrEMBL
      A0A571BE99
      Related
      ENSMUSP00000044858.7, ENSMUST00000048630.8
      Conserved Domains (3) summary
      pfam07593
      Location:461 → 513
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:560 → 606
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      42271474..42421405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251093.1 → XP_030106953.1  cartilage acidic protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (2) summary
      pfam07593
      Location:461 → 513
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    2. XM_006527372.4 → XP_006527435.1  cartilage acidic protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (3) summary
      pfam07645
      Location:560 → 606
      EGF_CA; Calcium-binding EGF domain
      pfam07593
      Location:461 → 513
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:300 → 364
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    3. XM_030251090.2 → XP_030106950.1  cartilage acidic protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (2) summary
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    4. XM_030251091.2 → XP_030106951.1  cartilage acidic protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (2) summary
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    5. XM_006527369.4 → XP_006527432.2  cartilage acidic protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (3) summary
      pfam07645
      Location:554 → 600
      EGF_CA; Calcium-binding EGF domain
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    6. XM_030251092.2 → XP_030106952.1  cartilage acidic protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (2) summary
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    7. XM_006527371.4 → XP_006527434.2  cartilage acidic protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (3) summary
      pfam07645
      Location:554 → 600
      EGF_CA; Calcium-binding EGF domain
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    8. XM_030251094.2 → XP_030106954.1  cartilage acidic protein 1 isoform X9

      Conserved Domains (3) summary
      pfam07645
      Location:237 → 283
      EGF_CA; Calcium-binding EGF domain
      pfam07593
      Location:138 → 190
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:30 → 100
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    9. XM_030251089.2 → XP_030106949.1  cartilage acidic protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A571BE99
      Conserved Domains (2) summary
      pfam07593
      Location:455 → 507
      UnbV_ASPIC; ASPIC and UnbV
      pfam13517
      Location:294 → 358
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R555.1 GenPept UniProtKB/Swiss-Prot:Q8R555

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