Hat1 histone aminotransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hat1provided by MGI
Official Full Name: histone aminotransferase 1provided by MGI
Primary source: MGI:MGI:96013
See related: Ensembl:ENSMUSG00000027018 AllianceGenome:MGI:96013
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KAT1; Hat-1; 2410071B14Rik
Summary: Predicted to enable H4 histone acetyltransferase activity. Predicted to be involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and histone H4 acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; liver; optic nerve; testis; and thymus primordium. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 51.2), placenta adult (RPKM 46.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 42.38 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (71219604..71271966)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (71389260..71441622)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Title: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Title: KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.
Histone acetyltransferase 1 is required for DNA replication fork function and stability.
Title: Histone acetyltransferase 1 is required for DNA replication fork function and stability.
The Hat1(-/-) MEFs exhibit mitochondrial defects suggesting a critical role for Hat1 in mitochondrial function. Taken together, these data show that loss of Hat1 induces multiple hallmarks of early-onset aging.
Title: Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1).
HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.
Title: HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.
Results suggests that Hat1-dependent acetylation of H4 is directly involved in the recruitment of several bromodomain-containing proteins to chromatin.
Title: Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly.
The acetyltransferase HAT1 moderates the NF-kappaB inflammatory response by regulating the transcription factor PLZF.
Title: The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.
Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly.
Title: Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.
Expression levels of Hat1 promoter mRNA are not significantly different in vitrified oocyte promoter compared with fresh oocytes.
Title: Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124502 (e-PCR)
- UniSTS:161324

BI285581 (e-PCR)
- UniSTS:244797

MARC_12189-12190:1004712897:1 (e-PCR)
- UniSTS:267358

MARC_12189-12190:1007747014:1 (e-PCR)
- UniSTS:267358

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in subtelomeric heterochromatin formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone acetyltransferase type B catalytic subunit

Names: histidine aminotransferase 1; histone acetyltransferase 1

NP_080391.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026115.4 → NP_080391.2 histone acetyltransferase type B catalytic subunit

See identical proteins and their annotated locations for NP_080391.2

Status: PROVISIONAL

Source sequence(s)

AK041700

Consensus CDS

CCDS16114.1

UniProtKB/Swiss-Prot

Q8BY71

UniProtKB/TrEMBL

A2ATU9

Related

ENSMUSP00000028408.3, ENSMUST00000028408.3

Conserved Domains (3) summary

pfam10394
Location:22 → 184

Hat1_N; Histone acetyl transferase HAT1 N-terminus

pfam13673
Location:181 → 285

Acetyltransf_10; Acetyltransferase (GNAT) domain

cl05000
Location:323 → 408

CHASE3; CHASE3 domain