Hlf hepatic leukemia factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hlfprovided by MGI
Official Full Name: hepatic leukemia factorprovided by MGI
Primary source: MGI:MGI:96108
See related: Ensembl:ENSMUSG00000003949 AllianceGenome:MGI:96108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E230015K02Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 20.3), frontal lobe adult (RPKM 15.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 55.03 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (90227361..90281745, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90336535..90390917, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Title: Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors
Title: Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.
HLF-deficient hematopoietic stem cells display loss of quiescence and increased sensitivity to chemotoxic insults.
Title: Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity
Title: Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.
Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Title: Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.
Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1.
Title: MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
Title: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
Title: Molecular clock is involved in predictive circadian adjustment of renal function.
mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain
Title: The loss of circadian PAR bZip transcription factors results in epilepsy.
The HLF protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
Title: The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hlf (e-PCR), detects polymorphism
- UniSTS:506978

WI-7705 (e-PCR)
- UniSTS:42341

RH131452 (e-PCR)
- UniSTS:214735

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hepatic leukemia factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403985.1 → NP_001390914.1 hepatic leukemia factor isoform 2

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403986.1 → NP_001390915.1 hepatic leukemia factor isoform 3

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403988.1 → NP_001390917.1 hepatic leukemia factor isoform 4

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403989.1 → NP_001390918.1 hepatic leukemia factor isoform 4

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403991.1 → NP_001390920.1 hepatic leukemia factor isoform 4

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403993.1 → NP_001390922.1 hepatic leukemia factor isoform 5

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403995.1 → NP_001390924.1 hepatic leukemia factor isoform 5

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_001403997.1 → NP_001390926.1 hepatic leukemia factor isoform 5

Status: VALIDATED

Source sequence(s)

AL626785, AL691494
NM_172563.4 → NP_766151.1 hepatic leukemia factor isoform 1

See identical proteins and their annotated locations for NP_766151.1

Status: VALIDATED

Source sequence(s)

AL626785, AL691494

Consensus CDS

CCDS25241.1

UniProtKB/Swiss-Prot

Q6PF83, Q8BW74

UniProtKB/TrEMBL

Q8BVB2

Related

ENSMUSP00000004051.8, ENSMUST00000004051.8

Conserved Domains (1) summary

cd14695
Location:224 → 283

bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain