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    Rap1gap2 RAP1 GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 380711, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rap1gap2provided by MGI
    Official Full Name
    RAP1 GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:3028623
    See related
    Ensembl:ENSMUSG00000038807 AllianceGenome:MGI:3028623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Garnl4; Gm1561; mKIAA1039
    Summary
    Enables GTPase activator activity. Acts upstream of or within negative regulation of neuron projection development. Located in cytoplasm and neuron projection. Is expressed in olfactory epithelium; pancreas; and pancreas epithelium. Orthologous to human RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 24.4), frontal lobe adult (RPKM 21.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 45.76 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74274182..74501796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74383356..74610915, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 1D Neighboring gene olfactory receptor family 1 subfamily D member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7014 Neighboring gene STARR-seq mESC enhancer starr_29957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74369680-74369789 Neighboring gene STARR-seq mESC enhancer starr_29960 Neighboring gene STARR-seq mESC enhancer starr_29961 Neighboring gene STARR-seq mESC enhancer starr_29962 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene STARR-positive B cell enhancer ABC_E3971 Neighboring gene clustered mitochondria homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth. Imai K, et al. Gene, 2005 Dec 30. PMID 16169686
    2. Rap1gap2 regulates axon outgrowth in olfactory sensory neurons. Sadrian B, et al. Mol Cell Neurosci, 2012 Jul. PMID 22732430
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rap1gap2 overexpression limits neurite outgrowth and branching in Neuro-2a cells, and counteracts Rap1-induced augmentation of neurite outgrowth
      Title: Rap1gap2 regulates axon outgrowth in olfactory sensory neurons.
    2. Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)
      Title: Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130388

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rap1 GTPase-activating protein 2
    Names
    GTPase activating RANGAP domain-like 4
    GTPase-activating Rap/Ran-GAP domain-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015046.3 → NP_001015046.1  rap1 GTPase-activating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001015046.1

      Status: VALIDATED

      Source sequence(s)
      AK038834, AK147290, AL604065, AW457490, CJ106176
      Consensus CDS
      CCDS25032.1
      UniProtKB/Swiss-Prot
      Q3KNA3, Q3V3L0, Q5SVL6, Q80TL8
      UniProtKB/TrEMBL
      A0A171EBK8
      Related
      ENSMUSP00000099580.2, ENSMUST00000102521.9
      Conserved Domains (1) summary
      pfam02145
      Location:259 → 438
      Rap_GAP; Rap/ran-GAP

    2. NM_001364131.1 → NP_001351060.1  rap1 GTPase-activating protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348
      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:287 → 466
      Rap_GAP; Rap/ran-GAP

    3. NM_001364132.1 → NP_001351061.1  rap1 GTPase-activating protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348, AL645971
      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:257 → 436
      Rap_GAP; Rap/ran-GAP

    4. NM_001401658.1 → NP_001388587.1  rap1 GTPase-activating protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348

    RNA

    1. NR_157089.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348, AL645971
      Related
      ENSMUST00000047488.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74274182..74501796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533622.4 → XP_006533685.2  rap1 GTPase-activating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A171EBK8, A0A571BED8
      Related
      ENSMUSP00000158689.2, ENSMUST00000238457.2
      Conserved Domains (1) summary
      pfam02145
      Location:319 → 498
      Rap_GAP; Rap/ran-GAP

    2. XM_036156817.1 → XP_036012710.1  rap1 GTPase-activating protein 2 isoform X9

      Conserved Domains (1) summary
      pfam02145
      Location:210 → 389
      Rap_GAP; Rap/ran-GAP

    3. XM_036156816.1 → XP_036012709.1  rap1 GTPase-activating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:225 → 404
      Rap_GAP; Rap/ran-GAP

    4. XM_030246102.2 → XP_030101962.1  rap1 GTPase-activating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:244 → 423
      Rap_GAP; Rap/ran-GAP

    5. XM_006533624.3 → XP_006533687.1  rap1 GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:337 → 516
      Rap_GAP; Rap/ran-GAP

    6. XM_006533628.3 → XP_006533691.1  rap1 GTPase-activating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:256 → 435
      Rap_GAP; Rap/ran-GAP

    7. XM_006533629.3 → XP_006533692.1  rap1 GTPase-activating protein 2 isoform X6

      Conserved Domains (1) summary
      pfam02145
      Location:232 → 411
      Rap_GAP; Rap/ran-GAP

    8. XM_006533631.4 → XP_006533694.1  rap1 GTPase-activating protein 2 isoform X8

      Conserved Domains (1) summary
      pfam02145
      Location:217 → 396
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SVL6.1 GenPept UniProtKB/Swiss-Prot:Q5SVL6

    Gene LinkOut

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