Tmem106b transmembrane protein 106B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem106bprovided by MGI
Official Full Name: transmembrane protein 106Bprovided by MGI
Primary source: MGI:MGI:1919150
See related: Ensembl:ENSMUSG00000029571 AllianceGenome:MGI:1919150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310036D22Rik; 5830455K21Rik; 6430519M21Rik
Summary: Enables ATPase binding activity. Acts upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Located in lysosome. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 21.1), bladder adult (RPKM 15.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 5.38 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (13069758..13089268)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (13069759..13089269)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Title: Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.
Title: TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.
TMEM106B regulates microglial proliferation and survival in response to demyelination.
Title: TMEM106B regulates microglial proliferation and survival in response to demyelination.
Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
Title: Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
Title: TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
Title: Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Title: Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
Title: Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
Title: Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
Progranulin and TMEM106B: when two become wan.
Title: Progranulin and TMEM106B: when two become wan.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA987036 (e-PCR)
- UniSTS:159886

AI661344 (e-PCR)
- UniSTS:164313

AI428776 (e-PCR)
- UniSTS:159486

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATPase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lysosomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 106B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.