Ccnt2 cyclin T2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnt2provided by MGI
Official Full Name: cyclin T2provided by MGI
Primary source: MGI:MGI:1920199
See related: Ensembl:ENSMUSG00000026349 AllianceGenome:MGI:1920199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CycT2; CycT2a; CycT2b; 2900041I18Rik
Summary: Enables chromatin binding activity. Involved in skeletal muscle tissue development. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and lens primordium. Orthologous to human CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 19.4), CNS E14 (RPKM 19.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E3; 1 55.8 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (127701901..127732574)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (127774164..127804837)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both isoforms of Cyclin T2 are able to activate the myogenic program but Cyclin T2b has a predominant role, in particular during the latest stages.
Title: Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation.
miR-15a inhibited muscle differentiation at least in part by targeting Ccnt2; roles in spermatogenesis.
Title: Cyclin T2: a novel miR-15a target gene involved in early spermatogenesis.
despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes
Title: Cyclin T2 is essential for mouse embryogenesis.
activation of MyoD-dependent transcription by cdk9/cyclin T2
Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ccnt2 (e-PCR), detects polymorphism
- UniSTS:498738

BQ198886 (e-PCR)
- UniSTS:260980

RH127051 (e-PCR)
- UniSTS:209782

NoName (e-PCR)
- UniSTS:234208

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 7SK snRNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in early viral transcription	ISO Inferred from Sequence Orthology more info
involved_in late viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin/CDK positive transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-T2

Names: cyclin T2a; cyclin T2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028399.1 → NP_082675.1 cyclin-T2

See identical proteins and their annotated locations for NP_082675.1

Status: VALIDATED

Source sequence(s)

BB511168, BC054122, BG277049

Consensus CDS

CCDS15248.1

UniProtKB/Swiss-Prot

K4N0L9, K4N2S3, Q7TQK0

UniProtKB/TrEMBL

Q3U832

Related

ENSMUSP00000027587.9, ENSMUST00000027587.15

Conserved Domains (2) summary

COG5333
Location:8 → 216

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

cd00043
Location:36 → 108

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...