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    Exoc3l exocyst complex component 3-like [ Mus musculus (house mouse) ]

    Gene ID: 277978, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Exoc3lprovided by MGI
    Official Full Name
    exocyst complex component 3-likeprovided by MGI
    Primary source
    MGI:MGI:3041195
    See related
    Ensembl:ENSMUSG00000043251 AllianceGenome:MGI:3041195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Exoc3l1; C730015A04Rik
    Summary
    Predicted to enable SNARE binding activity. Involved in exocytosis and peptide hormone secretion. Located in secretory granule. Part of exocyst. Is expressed in several structures, including adrenal gland; lung; meninges; olfactory lobe; and vertebral axis musculature. Orthologous to human EXOC3L1 (exocyst complex component 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 17.2), lung adult (RPKM 13.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106016555..106024258, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105289923..105296966, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 4 Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1768 Neighboring gene STARR-positive B cell enhancer ABC_E3797 Neighboring gene uncharacterized LOC102636360 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549
    2. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
      Title: Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exocyst complex component 3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357379.2 → NP_001344308.1  exocyst complex component 3-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Conserved Domains (1) summary
      cl19885
      Location:1 → 373
      Sec6; Exocyst complex component Sec6

    2. NM_001428421.1 → NP_001415350.1  exocyst complex component 3-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124584
      UniProtKB/Swiss-Prot
      Q3USB8, Q8BI71

    3. NM_001428422.1 → NP_001415351.1  exocyst complex component 3-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124584

    4. NM_001428423.1 → NP_001415352.1  exocyst complex component 3-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124584

    5. NM_177788.6 → NP_808456.1  exocyst complex component 3-like protein isoform 1

      See identical proteins and their annotated locations for NP_808456.1

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS22597.1
      UniProtKB/Swiss-Prot
      Q3USB8, Q8BI71
      UniProtKB/TrEMBL
      Q3T9C8
      Related
      ENSMUSP00000053766.4, ENSMUST00000057855.4
      Conserved Domains (1) summary
      pfam06046
      Location:189 → 722
      Sec6; Exocyst complex component Sec6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106016555..106024258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154085.1 → XP_036009978.1  exocyst complex component 3-like protein isoform X2

      Conserved Domains (1) summary
      cl19885
      Location:1 → 373
      Sec6; Exocyst complex component Sec6

    2. XM_036154084.1 → XP_036009977.1  exocyst complex component 3-like protein isoform X2

      Conserved Domains (1) summary
      cl19885
      Location:1 → 373
      Sec6; Exocyst complex component Sec6

    3. XM_006531070.4 → XP_006531133.1  exocyst complex component 3-like protein isoform X1

      Conserved Domains (1) summary
      pfam06046
      Location:189 → 722
      Sec6; Exocyst complex component Sec6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI71.1 GenPept UniProtKB/Swiss-Prot:Q8BI71

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