Exoc5 exocyst complex component 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc5provided by MGI
Official Full Name: exocyst complex component 5provided by MGI
Primary source: MGI:MGI:2145645
See related: Ensembl:ENSMUSG00000061244 AllianceGenome:MGI:2145645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm76; SEC10; PRO1912; Sec10l1
Summary: Enables protein N-terminus binding activity. Involved in protein localization to plasma membrane. Acts upstream of with a negative effect on epithelial cell apoptotic process. Acts upstream of or within establishment of planar polarity and non-motile cilium assembly. Predicted to be located in cytosol. Predicted to be part of exocyst. Used to study obstructive nephropathy. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.7), CNS E14 (RPKM 11.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 25.36 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (49249379..49304124, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (49011922..49066667, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Title: Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function.
Title: Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function.
Loss of EXOC5 is associated with podocyte loss and dysfunction.
Title: Disruption of the exocyst induces podocyte loss and dysfunction.
Exoc5 is essential for the normal development and survival of cochlear hair cells and Spiral Ganglion Neurons, as well as the functional maintenance of hearing.
Title: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.
Downregulation of Sec10 following ischemia-reperfusion injury appears to accelerate recovery of kidney tubule cells through activated ruffle formation and enhanced cell migration.
Title: Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration.
Findings show exocyst complex component 5 protein Sec10 is critical for the development of the urothelium in ureters.
Title: Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions.
Sec10-knockout mouse model revealed significant defects in renal tubule epithelial cells.
Title: The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI447711 (e-PCR)
- UniSTS:165904

AI448003 (e-PCR)
- UniSTS:180643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_negative_effect epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
part_of exocyst	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: exocyst complex component 5

Names: SEC10-like 1; exocyst complex component Sec10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207214.3 → NP_997097.1 exocyst complex component 5

See identical proteins and their annotated locations for NP_997097.1

Status: VALIDATED

Source sequence(s)

AK134562, AK164067, AV025936, CT025618

Consensus CDS

CCDS49474.1

UniProtKB/Swiss-Prot

Q3TPX4, Q80VK3

UniProtKB/TrEMBL

Q3U8A5

Related

ENSMUSP00000125434.2, ENSMUST00000162175.9

Conserved Domains (1) summary

pfam07393
Location:89 → 707

Sec10; Exocyst complex component Sec10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

49249379..49304124 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315766.2 → XP_017171255.1 exocyst complex component 5 isoform X3

UniProtKB/TrEMBL

Q3U8A5

Conserved Domains (2) summary

pfam07393
Location:89 → 660

Sec10; Exocyst complex component Sec10

pfam10267
Location:25 → 84

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_011244884.4 → XP_011243186.1 exocyst complex component 5 isoform X2

UniProtKB/TrEMBL

Q3U8A5

Conserved Domains (2) summary

pfam07393
Location:89 → 675

Sec10; Exocyst complex component Sec10

pfam10267
Location:25 → 84

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_011244883.4 → XP_011243185.1 exocyst complex component 5 isoform X1

UniProtKB/TrEMBL

Q3U8A5

Conserved Domains (2) summary

pfam07393
Location:89 → 714

Sec10; Exocyst complex component Sec10

pfam10267
Location:25 → 84

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_036158363.1 → XP_036014256.1 exocyst complex component 5 isoform X4

Conserved Domains (1) summary

pfam07393
Location:89 → 432

Sec10; Exocyst complex component Sec10