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    Capn13 calpain 13 [ Mus musculus (house mouse) ]

    Gene ID: 381122, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Capn13provided by MGI
    Official Full Name
    calpain 13provided by MGI
    Primary source
    MGI:MGI:2685789
    See related
    Ensembl:ENSMUSG00000043705 AllianceGenome:MGI:2685789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm943; CANP 13
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in negative regulation of apoptotic process and proteolysis. Predicted to be active in cytoplasm. Orthologous to human CAPN13 (calpain 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 6.9), colon adult (RPKM 6.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E2; 17 44.84 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73613451..73706376, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73306456..73399381, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lysocardiolipin acyltransferase 1 Neighboring gene predicted gene, 25406 Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E398 Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene STARR-seq mESC enhancer starr_43202 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 14 Neighboring gene predicted gene, 46602 Neighboring gene predicted gene, 52320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SHARPIN negatively associates with TRAF2-mediated NFκB activation. Liang Y. PLoS One, 2011. PMID 21829440, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calpain-13
    Names
    calcium-activated neutral proteinase 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033444.2 → NP_001028616.1  calpain-13

      See identical proteins and their annotated locations for NP_001028616.1

      Status: PROVISIONAL

      Source sequence(s)
      AK136569
      Consensus CDS
      CCDS37690.1
      UniProtKB/Swiss-Prot
      B2RW21, Q3UW68
      Related
      ENSMUSP00000092832.4, ENSMUST00000095208.4
      Conserved Domains (2) summary
      pfam00648
      Location:31 → 327
      Peptidase_C2; Calpain family cysteine protease
      cl00165
      Location:343 → 469
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      73613451..73706376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317548.2 → XP_017173037.1  calpain-13 isoform X1

      Conserved Domains (3) summary
      cd16195
      Location:340 → 500
      EFh_PEF_CAPN13_14; Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins
      pfam00648
      Location:16 → 162
      Peptidase_C2; Calpain family cysteine protease
      cl00165
      Location:201 → 304
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

    2. XM_006524535.2 → XP_006524598.1  calpain-13 isoform X2

      Conserved Domains (1) summary
      pfam00648
      Location:31 → 327
      Peptidase_C2; Calpain family cysteine protease

    RNA

    1. XR_001782085.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UW68.1 GenPept UniProtKB/Swiss-Prot:Q3UW68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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