Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gga3provided by MGI
Official Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3provided by MGI
Primary source: MGI:MGI:2384159
See related: Ensembl:ENSMUSG00000020740 AllianceGenome:MGI:2384159
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0154; C230037M19Rik
Summary: Predicted to enable small GTPase binding activity and ubiquitin binding activity. Acts upstream of or within positive regulation of protein catabolic process and protein localization to lysosome. Predicted to be located in endosome; lysosome; and trans-Golgi network. Predicted to be part of protein-containing complex. Is expressed in several structures, including heart; liver; lung; metanephros; and white fat. Orthologous to human GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 30.1), spleen adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.89 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115475081..115495501, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115584255..115604517, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
Title: Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
GGA3 plays a key role in GABAergic transmission. GGA3 deletion results in decreased anxiety-like behaviors and increased BACE1 levels.
Title: Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.
depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury
Title: Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery
Title: Ubiquitin regulates GGA3-mediated degradation of BACE1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-binding protein GGA3

Names: golgi-localized, gamma ear-containing, ARF-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252067.2 → NP_001238996.1 ADP-ribosylation factor-binding protein GGA3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AL645470

Consensus CDS

CCDS56817.1

UniProtKB/TrEMBL

A2A9W7

Related

ENSMUSP00000102117.4, ENSMUST00000106508.10

Conserved Domains (3) summary

smart00809
Location:518 → 632

Alpha_adaptinC2; Adaptin C-terminal domain

cd03567
Location:8 → 146

VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...

cd14240
Location:213 → 299

GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
NM_173048.4 → NP_766636.2 ADP-ribosylation factor-binding protein GGA3 isoform 1

See identical proteins and their annotated locations for NP_766636.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL645470

Consensus CDS

CCDS25641.1

UniProtKB/Swiss-Prot

Q3V1Y0, Q80U71, Q8BMI3

UniProtKB/TrEMBL

S4R2D2

Related

ENSMUSP00000019135.8, ENSMUST00000019135.14

Conserved Domains (3) summary

smart00809
Location:596 → 710

Alpha_adaptinC2; Adaptin C-terminal domain

cd03567
Location:8 → 146

VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...

cd14240
Location:213 → 299

GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115475081..115495501 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533365.5 → XP_006533428.1 ADP-ribosylation factor-binding protein GGA3 isoform X1

UniProtKB/TrEMBL

S4R2D2

Conserved Domains (5) summary

PHA03247
Location:334 → 669

PHA03247; large tegument protein UL36; Provisional

cd14240
Location:213 → 299

GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

cd17008
Location:6 → 146

VHS_GGA3; VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA3

pfam02883
Location:593 → 682

Alpha_adaptinC2; Adaptin C-terminal domain

pfam18308
Location:169 → 207

GGA_N-GAT; GGA N-GAT domain
XM_011249031.3 → XP_011247333.1 ADP-ribosylation factor-binding protein GGA3 isoform X2

Conserved Domains (4) summary

smart00809
Location:460 → 574

Alpha_adaptinC2; Adaptin C-terminal domain

PHA03247
Location:198 → 533

PHA03247; large tegument protein UL36; Provisional

cd14240
Location:77 → 163

GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

pfam18308
Location:33 → 71

GGA_N-GAT; GGA N-GAT domain
XM_011249032.1 → XP_011247334.1 ADP-ribosylation factor-binding protein GGA3 isoform X3

Conserved Domains (3) summary

smart00809
Location:366 → 480

Alpha_adaptinC2; Adaptin C-terminal domain

PHA03247
Location:104 → 439

PHA03247; large tegument protein UL36; Provisional

cd14240
Location:1 → 69

GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3