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    Dtymk deoxythymidylate kinase [ Mus musculus (house mouse) ]

    Gene ID: 21915, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dtymkprovided by MGI
    Official Full Name
    deoxythymidylate kinaseprovided by MGI
    Primary source
    MGI:MGI:108396
    See related
    Ensembl:ENSMUSG00000026281 AllianceGenome:MGI:108396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmk; CDC8; TMPK; TYPK; mtmk; D10Ertd203e
    Summary
    Enables thymidylate kinase activity. Acts upstream of or within cellular response to growth factor stimulus and dTDP biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; midbrain; and respiratory system. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 57.9), liver E14 (RPKM 48.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 D; 1 47.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93720298..93730246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93792576..93802068, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene THAP domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_01735 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene STARR-positive B cell enhancer ABC_E4338 Neighboring gene predicted gene, 22089 Neighboring gene inhibitor of growth family, member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7734 Neighboring gene D-2-hydroxyglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the murine thymidylate kinase gene. Liang P, et al. Cell Growth Differ, 1995 Oct. PMID 8845311
    2. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Moon S, et al. Cell Death Dis, 2018 Nov 2. PMID 30389914, Free PMC Article
    3. Gene expression profile of aging and its retardation by caloric restriction. Lee CK, et al. Science, 1999 Aug 27. PMID 10464095
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dTDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTTP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleoside monophosphate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate kinase
    Names
    dTMP kinase
    NP_001099137.1
    NP_075625.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105667.1 → NP_001099137.1  thymidylate kinase isoform 1

      See identical proteins and their annotated locations for NP_001099137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AI462533, BY098372, C78743, CB182101
      Consensus CDS
      CCDS48329.1
      UniProtKB/Swiss-Prot
      P97930, Q8C2L0, Q8K2S2
      Related
      ENSMUSP00000027503.8, ENSMUST00000027503.14
      Conserved Domains (1) summary
      PLN02924
      Location:5 → 211
      PLN02924; thymidylate kinase

    2. NM_023136.2 → NP_075625.1  thymidylate kinase isoform 2

      See identical proteins and their annotated locations for NP_075625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and lacks much of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AA014471, BY098372, CF983443
      Consensus CDS
      CCDS35672.1
      UniProtKB/TrEMBL
      Q6GRA7
      Related
      ENSMUSP00000108511.3, ENSMUST00000112890.3
      Conserved Domains (1) summary
      cl17190
      Location:5 → 78
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93720298..93730246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954565.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97930.2 GenPept UniProtKB/Swiss-Prot:P97930

    Gene LinkOut

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