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    Rgma repulsive guidance molecule family member A [ Mus musculus (house mouse) ]

    Gene ID: 244058, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rgmaprovided by MGI
    Official Full Name
    repulsive guidance molecule family member Aprovided by MGI
    Primary source
    MGI:MGI:2679262
    See related
    Ensembl:ENSMUSG00000070509 AllianceGenome:MGI:2679262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230063O06
    Summary
    Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of GTPase activity; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 24.7), ovary adult (RPKM 23.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D1; 7 41.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73025268..73069647)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73375520..73419899)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19170 Neighboring gene predicted gene, 30075 Neighboring gene STARR-seq mESC enhancer starr_19173 Neighboring gene RIKEN cDNA 4930429H19 gene Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene STARR-seq mESC enhancer starr_19176 Neighboring gene predicted gene 44758 Neighboring gene STARR-seq mESC enhancer starr_19180 Neighboring gene STARR-seq mESC enhancer starr_19181 Neighboring gene chromodomain helicase DNA binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_19183 Neighboring gene STARR-seq mESC enhancer starr_19186 Neighboring gene STARR-seq mESC enhancer starr_19187 Neighboring gene STARR-positive B cell enhancer ABC_E6553 Neighboring gene CRISPRi-validated cis-regulatory element for Chaserr and Chd2 Neighboring gene CHD2 adjacent suppressive regulatory RNA Neighboring gene STARR-seq mESC enhancer starr_19190 Neighboring gene STARR-positive B cell enhancer ABC_E1342 Neighboring gene STARR-positive B cell enhancer ABC_E6554 Neighboring gene STARR-seq mESC enhancer starr_19193 Neighboring gene predicted gene, 30149 Neighboring gene predicted gene, 39036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro. Yuan X, et al. J Lipid Res, 2022 Oct. PMID 36089003, Free PMC Article
    2. Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer. Li Y, et al. Oncogene, 2022 Jan. PMID 34754080
    3. Repulsive Guidance Molecule A Suppresses Adult Neurogenesis. Isaksen TJ, et al. Stem Cell Reports, 2020 Apr 14. PMID 32243839, Free PMC Article
    4. Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. Körner A, et al. Nat Commun, 2019 Feb 7. PMID 30733433, Free PMC Article
    5. Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis. Tanabe S, et al. Cell Death Dis, 2018 Oct 17. PMID 30333477, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
      Title: RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
    2. RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
      Title: RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
    3. RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
      Title: RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
    4. Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
      Title: Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
    5. RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
      Title: RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
    6. Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
      Title: Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
    7. Inhibiting Rgma suppresses secondary progression in a mouse model of multiple sclerosis.
      Title: Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.
    8. After chronic morphine injection, Rgma was upregulated in C57BL/6J striatum.
      Title: Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.
    9. Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher.
      Title: Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.
    10. promotes dendritic cell maturation
      Title: A novel role for RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38550, MGC69915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coreceptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    repulsive guidance molecule A
    Names
    RGM domain family, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177740.5 → NP_808408.2  repulsive guidance molecule A precursor

      See identical proteins and their annotated locations for NP_808408.2

      Status: VALIDATED

      Source sequence(s)
      BC059072
      Consensus CDS
      CCDS21362.2
      UniProtKB/Swiss-Prot
      Q6PCX7, Q7TQ34, Q8CIH6
      Related
      ENSMUSP00000091870.6, ENSMUST00000094312.12
      Conserved Domains (2) summary
      pfam06534
      Location:227 → 410
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:48 → 222
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      73025268..73069647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540902.2 → XP_006540965.1  repulsive guidance molecule A isoform X1

      See identical proteins and their annotated locations for XP_006540965.1

      UniProtKB/Swiss-Prot
      Q6PCX7
      Related
      ENSMUSP00000145758.2, ENSMUST00000139780.3
      Conserved Domains (2) summary
      pfam06534
      Location:211 → 389
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:32 → 206
      RGM_N; Repulsive guidance molecule (RGM) N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCX7.1 GenPept UniProtKB/Swiss-Prot:Q6PCX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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