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    D630023F18Rik RIKEN cDNA D630023F18 gene [ Mus musculus (house mouse) ]

    Gene ID: 98303, updated on 5-Mar-2024

    Summary

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    Official Symbol
    D630023F18Rikprovided by MGI
    Official Full Name
    RIKEN cDNA D630023F18 geneprovided by MGI
    Primary source
    MGI:MGI:2138198
    See related
    Ensembl:ENSMUSG00000044816 AllianceGenome:MGI:2138198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Is expressed in brain; embryo; eye; and heart. Orthologous to human C2orf80 (chromosome 2 open reading frame 80). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 16.9), ovary adult (RPKM 1.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C2; 1 32.84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65144443..65162509, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65105284..65123351, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01174 Neighboring gene malic enzyme, supernatant pseudogene Neighboring gene crystallin, gamma A Neighboring gene predicted gene, 36358 Neighboring gene STARR-seq mESC enhancer starr_01175 Neighboring gene STARR-seq mESC enhancer starr_01176 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65224921-65225030 Neighboring gene isocitrate dehydrogenase 1 (NADP+), soluble Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65225772-65225881 Neighboring gene STARR-positive B cell enhancer ABC_E5765 Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene STARR-positive B cell enhancer ABC_E5766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Quintens R, et al. Biol Open, 2015 Feb 13. PMID 25681390, Free PMC Article
    2. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C2orf80 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285881.1 → NP_001272810.1  uncharacterized protein C2orf80 homolog isoform 2

      See identical proteins and their annotated locations for NP_001272810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC101869, AK085417, AK164708
      UniProtKB/TrEMBL
      B2RQD7

    2. NM_001285882.1 → NP_001272811.1  uncharacterized protein C2orf80 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate terminal exon, compared to variant 1. This results in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC101869, AK085417, AK164708
      Consensus CDS
      CCDS69896.1
      UniProtKB/TrEMBL
      D3YUK5
      Related
      ENSMUSP00000120090.2, ENSMUST00000148020.8

    3. NM_175293.4 → NP_780502.1  uncharacterized protein C2orf80 homolog isoform 1

      See identical proteins and their annotated locations for NP_780502.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
      Source sequence(s)
      AC101869, AK085417
      Consensus CDS
      CCDS15015.1
      UniProtKB/Swiss-Prot
      Q8C3M9
      Related
      ENSMUSP00000056196.4, ENSMUST00000050047.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65144443..65162509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243843.2 → XP_030099703.1  uncharacterized protein C2orf80 homolog isoform X3

      Conserved Domains (1) summary
      pfam17718
      Location:39 → 222
      DUF5563; Family of unknown function (DUF5563)

    2. XM_030243847.2 → XP_030099707.1  uncharacterized protein C2orf80 homolog isoform X4

      Conserved Domains (1) summary
      pfam17718
      Location:39 → 216
      DUF5563; Family of unknown function (DUF5563)

    3. XM_030243853.2 → XP_030099713.1  uncharacterized protein C2orf80 homolog isoform X5

      Conserved Domains (1) summary
      pfam17718
      Location:1 → 198
      DUF5563; Family of unknown function (DUF5563)

    4. XM_036154590.1 → XP_036010483.1  uncharacterized protein C2orf80 homolog isoform X8

      Conserved Domains (1) summary
      pfam17718
      Location:4 → 126
      DUF5563; Family of unknown function (DUF5563)

    5. XM_036154588.1 → XP_036010481.1  uncharacterized protein C2orf80 homolog isoform X7

      Conserved Domains (1) summary
      pfam17718
      Location:72 → 141
      DUF5563; Family of unknown function (DUF5563)

    6. XM_030243840.2 → XP_030099700.1  uncharacterized protein C2orf80 homolog isoform X1

      Conserved Domains (1) summary
      pfam17718
      Location:39 → 220
      DUF5563; Family of unknown function (DUF5563)

    7. XM_036154580.1 → XP_036010473.1  uncharacterized protein C2orf80 homolog isoform X2

      Conserved Domains (1) summary
      pfam17718
      Location:39 → 214
      DUF5563; Family of unknown function (DUF5563)

    8. XM_036154584.1 → XP_036010477.1  uncharacterized protein C2orf80 homolog isoform X6

      Conserved Domains (1) summary
      pfam17718
      Location:4 → 124
      DUF5563; Family of unknown function (DUF5563)

    RNA

    1. XR_003947354.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3M9.1 GenPept UniProtKB/Swiss-Prot:Q8C3M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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