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    Tatdn1 TatD DNase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69694, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tatdn1provided by MGI
    Official Full Name
    TatD DNase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916944
    See related
    Ensembl:ENSMUSG00000050891 AllianceGenome:MGI:1916944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDA11; 2310079P03Rik
    Summary
    Predicted to enable 3'-5'-exodeoxyribonuclease activity. Predicted to be located in nucleoplasm. Orthologous to human TATDN1 (TatD DNase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 4.9), liver E14 (RPKM 4.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D1; 15 25.09 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58762002..58805605, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58890153..58933756, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene ring finger protein 139 Neighboring gene STARR-seq mESC enhancer starr_38762 Neighboring gene STARR-positive B cell enhancer ABC_E8590 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8591 Neighboring gene RIKEN cDNA 4930544F09 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease TATDN1
    Names
    putative deoxyribonuclease TATDN1
    NP_001355357.1
    NP_001355557.1
    NP_001355558.1
    NP_001355559.1
    NP_001355560.1
    NP_001355561.1
    NP_001355562.1
    NP_001355563.1
    NP_001355564.1
    NP_001355565.1
    NP_780360.1
    XP_006521429.1
    XP_006521430.1
    XP_006521437.1
    XP_030104616.1
    XP_030104617.1
    XP_030104618.1
    XP_030104619.1
    XP_030104621.1
    XP_036015463.1
    XP_036015464.1
    XP_036015465.1
    XP_036015466.1
    XP_036015467.1
    XP_036015468.1
    XP_036015469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368428.1 → NP_001355357.1  deoxyribonuclease TATDN1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Consensus CDS
      CCDS88768.1
      UniProtKB/Swiss-Prot
      Q6P8M1, Q8BY37
      Related
      ENSMUSP00000154677.2, ENSMUST00000228538.3
      Conserved Domains (1) summary
      cd01310
      Location:6 → 294
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    2. NM_001368628.1 → NP_001355557.1  deoxyribonuclease TATDN1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:1 → 247
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    3. NM_001368629.1 → NP_001355558.1  deoxyribonuclease TATDN1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    4. NM_001368630.1 → NP_001355559.1  deoxyribonuclease TATDN1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    5. NM_001368631.1 → NP_001355560.1  deoxyribonuclease TATDN1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    6. NM_001368632.1 → NP_001355561.1  deoxyribonuclease TATDN1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    7. NM_001368633.1 → NP_001355562.1  deoxyribonuclease TATDN1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    8. NM_001368634.1 → NP_001355563.1  deoxyribonuclease TATDN1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cd01310
      Location:6 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    9. NM_001368635.1 → NP_001355564.1  deoxyribonuclease TATDN1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cl00281
      Location:1 → 179
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    10. NM_001368636.1 → NP_001355565.1  deoxyribonuclease TATDN1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Conserved Domains (1) summary
      cl00281
      Location:3 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    11. NM_175151.5 → NP_780360.1  deoxyribonuclease TATDN1 isoform 2

      See identical proteins and their annotated locations for NP_780360.1

      Status: VALIDATED

      Source sequence(s)
      AC158777
      Consensus CDS
      CCDS37082.1
      UniProtKB/TrEMBL
      A0A0R4J1E8
      Related
      ENSMUSP00000105783.2, ENSMUST00000110155.3
      Conserved Domains (1) summary
      cd01310
      Location:6 → 263
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58762002..58805605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521367.4 → XP_006521430.1  deoxyribonuclease TATDN1 isoform X2

      Conserved Domains (1) summary
      cd01310
      Location:13 → 278
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    2. XM_036159570.1 → XP_036015463.1  deoxyribonuclease TATDN1 isoform X2

      Conserved Domains (1) summary
      cd01310
      Location:13 → 278
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    3. XM_036159576.1 → XP_036015469.1  deoxyribonuclease TATDN1 isoform X6

      Conserved Domains (1) summary
      cl00281
      Location:3 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    4. XM_030248756.2 → XP_030104616.1  deoxyribonuclease TATDN1 isoform X3

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    5. XM_030248761.2 → XP_030104621.1  deoxyribonuclease TATDN1 isoform X6

      Conserved Domains (1) summary
      cl00281
      Location:3 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    6. XM_030248757.2 → XP_030104617.1  deoxyribonuclease TATDN1 isoform X3

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    7. XM_030248759.2 → XP_030104619.1  deoxyribonuclease TATDN1 isoform X5

      Conserved Domains (1) summary
      cl00281
      Location:1 → 179
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    8. XM_036159575.1 → XP_036015468.1  deoxyribonuclease TATDN1 isoform X6

      Conserved Domains (1) summary
      cl00281
      Location:3 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    9. XM_036159571.1 → XP_036015464.1  deoxyribonuclease TATDN1 isoform X3

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    10. XM_036159574.1 → XP_036015467.1  deoxyribonuclease TATDN1 isoform X6

      Conserved Domains (1) summary
      cl00281
      Location:3 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    11. XM_036159573.1 → XP_036015466.1  deoxyribonuclease TATDN1 isoform X3

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    12. XM_006521374.2 → XP_006521437.1  deoxyribonuclease TATDN1 isoform X3

      See identical proteins and their annotated locations for XP_006521437.1

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    13. XM_036159572.1 → XP_036015465.1  deoxyribonuclease TATDN1 isoform X3

      Conserved Domains (1) summary
      cd01310
      Location:3 → 226
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    14. XM_030248758.1 → XP_030104618.1  deoxyribonuclease TATDN1 isoform X4

      Conserved Domains (1) summary
      cl00281
      Location:6 → 195
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    15. XM_006521366.4 → XP_006521429.1  deoxyribonuclease TATDN1 isoform X1

      Conserved Domains (1) summary
      cd01310
      Location:6 → 263
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    RNA

    1. XR_003951437.2 RNA Sequence

    2. XR_004938870.1 RNA Sequence

      Related
      ENSMUST00000227540.2

    3. XR_003951436.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P8M1.1 GenPept UniProtKB/Swiss-Prot:Q6P8M1

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