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    Zfp78 zinc finger protein 78 [ Mus musculus (house mouse) ]

    Gene ID: 330463, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp78provided by MGI
    Official Full Name
    zinc finger protein 78provided by MGI
    Primary source
    MGI:MGI:107783
    See related
    Ensembl:ENSMUSG00000055150 AllianceGenome:MGI:107783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp77; KRAB12; A330079D15
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    7 A1; 7 3.69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6365812..6385605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6362809..6382606)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 583 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582 Neighboring gene STARR-positive B cell enhancer ABC_E8944 Neighboring gene STARR-positive B cell enhancer ABC_E442 Neighboring gene STARR-seq mESC enhancer starr_17978 Neighboring gene STARR-positive B cell enhancer ABC_E8150 Neighboring gene predicted gene, 53349 Neighboring gene zinc finger protein 28 Neighboring gene small integral membrane protein 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC102644

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 471

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025163.1 → NP_001020334.1  zinc finger protein 471 isoform 1

      See identical proteins and their annotated locations for NP_001020334.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK173164, BB603663, BY768295
      Consensus CDS
      CCDS20774.1
      UniProtKB/TrEMBL
      Q5U406
      Related
      ENSMUSP00000147154.2, ENSMUST00000207347.2
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:202 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001112805.1 → NP_001106276.1  zinc finger protein 471 isoform 2

      See identical proteins and their annotated locations for NP_001106276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK163133, AK173164, BB603663
      Consensus CDS
      CCDS20775.1
      UniProtKB/TrEMBL
      Q8BJ21
      Related
      ENSMUSP00000147228.2, ENSMUST00000208390.2
      Conserved Domains (3) summary
      COG5048
      Location:170 → 455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:231 → 251
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 54
      KRAB; KRAB box

    3. NM_177888.4 → NP_808556.1  zinc finger protein 471 isoform 2

      See identical proteins and their annotated locations for NP_808556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR but lacks a coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK039658, AK173164, BB603663
      Consensus CDS
      CCDS20775.1
      UniProtKB/TrEMBL
      Q8BJ21
      Related
      ENSMUSP00000146592.2, ENSMUST00000208030.2
      Conserved Domains (3) summary
      COG5048
      Location:170 → 455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:231 → 251
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 54
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6365812..6385605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540100.5 → XP_006540163.1  zinc finger protein 471 isoform X2

      See identical proteins and their annotated locations for XP_006540163.1

      UniProtKB/TrEMBL
      Q8BJ21
      Related
      ENSMUSP00000146578.2, ENSMUST00000207314.2
      Conserved Domains (3) summary
      COG5048
      Location:170 → 455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:231 → 251
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 54
      KRAB; KRAB box

    2. XM_017322306.3 → XP_017177795.1  zinc finger protein 471 isoform X1

      UniProtKB/TrEMBL
      Q5U406
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:202 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030242686.2 → XP_030098546.1  zinc finger protein 471 isoform X1

      UniProtKB/TrEMBL
      Q5U406
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:202 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017322307.3 → XP_017177796.1  zinc finger protein 471 isoform X1

      UniProtKB/TrEMBL
      Q5U406
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:202 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036153176.1 → XP_036009069.1  zinc finger protein 471 isoform X1

      UniProtKB/TrEMBL
      Q5U406
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:202 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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