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    Adnp2 ADNP homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 240442, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adnp2provided by MGI
    Official Full Name
    ADNP homeobox 2provided by MGI
    Primary source
    MGI:MGI:2448562
    See related
    Ensembl:ENSMUSG00000053950 AllianceGenome:MGI:2448562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp508; Kiaa0863; mKIAA0863; 8430420L05Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; brain; genitourinary system; pancreas; and retina nuclear layer. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.9), placenta adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E3; 18 53.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80169523..80195284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80126315..80151516, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 pseudogene Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene VISTA enhancer mm1711 Neighboring gene STARR-seq mESC enhancer starr_45165 Neighboring gene STARR-positive B cell enhancer ABC_E497 Neighboring gene predicted gene, 41787 Neighboring gene phosphoglycerate mutase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress. Kushnir M, et al. J Neurochem, 2008 Apr. PMID 18179478
    2. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Li L, et al. Cell Rep, 2019 Jul 16. PMID 31315048
    3. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the adnp2 may have an important function in brain by playing a role in cellular survival pathways.
      Title: Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38953

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activity-dependent neuroprotector homeobox protein 2
    Names
    ADNP homeobox protein 2
    zinc finger protein 508

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175028.1 → NP_778193.1  activity-dependent neuroprotector homeobox protein 2

      See identical proteins and their annotated locations for NP_778193.1

      Status: VALIDATED

      Source sequence(s)
      AB093268, BC024969
      Consensus CDS
      CCDS50332.1
      UniProtKB/Swiss-Prot
      Q6P294, Q80VS0, Q811H5, Q8CHC8, Q8R1A2
      Related
      ENSMUSP00000068560.9, ENSMUST00000066743.11
      Conserved Domains (3) summary
      smart00389
      Location:1082 → 1126
      HOX; Homeodomain
      PHA03247
      Location:268 → 695
      PHA03247; large tegument protein UL36; Provisional
      pfam18868
      Location:907 → 970
      zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80169523..80195284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526466.4 → XP_006526529.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006526529.1

      UniProtKB/Swiss-Prot
      Q6P294, Q80VS0, Q811H5, Q8CHC8, Q8R1A2
      Conserved Domains (3) summary
      smart00389
      Location:1082 → 1126
      HOX; Homeodomain
      PHA03247
      Location:268 → 695
      PHA03247; large tegument protein UL36; Provisional
      pfam18868
      Location:907 → 970
      zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

    2. XM_036161143.1 → XP_036017036.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

      Conserved Domains (2) summary
      smart00389
      Location:978 → 1022
      HOX; Homeodomain
      PHA03247
      Location:164 → 591
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHC8.2 GenPept UniProtKB/Swiss-Prot:Q8CHC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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