Itgae integrin alpha E, epithelial-associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgaeprovided by MGI
Official Full Name: integrin alpha E, epithelial-associatedprovided by MGI
Primary source: MGI:MGI:1298377
See related: Ensembl:ENSMUSG00000005947 AllianceGenome:MGI:1298377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD103; aM290; alpha-E1; A530055J10; alpha-M290
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.22 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72981396..73038272)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73090505..73147449)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
Immunological characteristics of CD103[+]CD8[+] Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
Title: Immunological characteristics of CD103(+)CD8(+) Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Title: γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
Title: Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.
Title: Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
Title: The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
Title: Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
Title: Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Title: CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Jcs2 (e-PCR), detects polymorphism
- UniSTS:461960

UniSTS:237527 (e-PCR)
- UniSTS:237527

U12236 (e-PCR)
- UniSTS:125670

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-E

Names: integrin alpha M290

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361245.2 → NP_001348174.1 integrin alpha-E isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL670399

UniProtKB/TrEMBL

Q3U4V9

Conserved Domains (3) summary

smart00191
Location:565 → 624

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:195 → 370

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:667 → 938

Integrin_alpha2; Integrin alpha
NM_008399.4 → NP_032425.2 integrin alpha-E isoform 1 precursor

See identical proteins and their annotated locations for NP_032425.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL670399

Consensus CDS

CCDS24995.1

UniProtKB/Swiss-Prot

B1AUD5, Q60677

UniProtKB/TrEMBL

A2T0Z1, Q3U4V9

Related

ENSMUSP00000006101.4, ENSMUST00000006101.4

Conserved Domains (3) summary

smart00191
Location:566 → 625

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:196 → 371

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:668 → 939

Integrin_alpha2; Integrin alpha

RNA

NR_189133.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670399
NR_189134.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670399
NR_189135.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670399
NR_189136.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670399

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

72981396..73038272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_172944.2: Suppressed sequence

Description

NM_172944.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.