Sostdc1 sclerostin domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sostdc1provided by MGI
Official Full Name: sclerostin domain containing 1provided by MGI
Primary source: MGI:MGI:1913292
See related: Ensembl:ENSMUSG00000036169 AllianceGenome:MGI:1913292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wise; Sostl; USAG-1; ectodin; 0610006G05Rik
Summary: Predicted to enable BMP binding activity and BMP receptor activity. Acts upstream of or within several processes, including animal organ development; negative regulation of cell fate commitment; and negative regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human SOSTDC1 (sclerostin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 25.1), limb E14.5 (RPKM 13.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 16.82 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (36364168..36368451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (36314169..36318452)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice.
Title: Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice.
Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice.
Title: Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice.
SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.
Title: SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.
sclerostin domain containing 1 (Sostdc1) is expressed at low levels in multiple myeloma and osteoblast lineage cells when these cells are grown separately in cell culture but its expression is significantly induced in both cell types when these cells are in contact.
Title: Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells.
these data support a role for Sostdc1 in the regulation of NK cell maturation and cytotoxicity, and identify potential NK cell niches.
Title: Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.
Wise and Lrp4 are thus likely to control palatal rugae development by regulating reaction-diffusion mechanisms through Shh and Fgf signaling.
Title: Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.
Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum.
Title: Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.
suggest that RUNX2 and USAG-1 act in an antagonistic manner
Title: Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development.
the in vivo inter-relationships between Bmp7 and Usag-1, was examined.
Title: Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis.
Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling.
Title: Wise regulates bone deposition through genetic interactions with Lrp5.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (10) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sostdc1 (e-PCR), detects polymorphism
- UniSTS:471847

UniSTS:464692 (e-PCR)
- UniSTS:464692

Sostdc1 (e-PCR), detects polymorphism
- UniSTS:464692

Sostdc1 (e-PCR), detects polymorphism
- UniSTS:532289

Sostl (e-PCR), detects polymorphism
- UniSTS:257006

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sclerostin domain-containing protein 1

Names: cystine-knot containing secreted protein; ectodermal BMP inhibitor; sclerostin-like protein; uterine sensitization-associated gene 1 protein; uterine sensitization-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.