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    Pipox pipecolic acid oxidase [ Mus musculus (house mouse) ]

    Gene ID: 19193, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pipoxprovided by MGI
    Official Full Name
    pipecolic acid oxidaseprovided by MGI
    Primary source
    MGI:MGI:1197006
    See related
    Ensembl:ENSMUSG00000017453 AllianceGenome:MGI:1197006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pso; LPIPOX
    Summary
    Predicted to enable L-pipecolate oxidase activity and sarcosine oxidase activity. Predicted to be involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate. Located in peroxisome. Is expressed in alimentary system; liver; nervous system; and urinary system. Orthologous to human PIPOX (pipecolic acid and sarcosine oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 95.8), liver adult (RPKM 89.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77771440..77784698, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77880614..77893872, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin XVIIIA Neighboring gene STARR-seq mESC enhancer starr_30068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77605328-77605830 Neighboring gene STARR-seq mESC enhancer starr_30070 Neighboring gene predicted gene 10277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77616184-77616337 Neighboring gene predicted gene, 36875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77700892-77701111 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77701174-77701361 Neighboring gene STARR-seq mESC enhancer starr_30074 Neighboring gene predicted gene, 29932 Neighboring gene STARR-seq mESC enhancer starr_30076 Neighboring gene VISTA enhancer mm981 Neighboring gene predicted gene, 29979 Neighboring gene predicted gene 11190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1. Herbst R, et al. Genomics, 1997 Dec 15. PMID 9441754
    2. L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. Dodt G, et al. Biochem J, 2000 Feb 1. PMID 10642506, Free PMC Article
    3. Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. Mohammed Y, et al. NPJ Syst Biol Appl, 2021 May 28. PMID 34050187, Free PMC Article
    4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-pipecolate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-pipecolate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-pipecolate oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sarcosine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sarcosine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sarcosine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal sarcosine oxidase
    Names
    L-pipecolate oxidase
    L-pipecolic acid oxidase
    NP_032978.2
    XP_011247109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008952.2 → NP_032978.2  peroxisomal sarcosine oxidase

      See identical proteins and their annotated locations for NP_032978.2

      Status: VALIDATED

      Source sequence(s)
      AK149488, BB561815, BY708439, U94700
      Consensus CDS
      CCDS25086.1
      UniProtKB/Swiss-Prot
      O55223, Q9D826
      UniProtKB/TrEMBL
      Q3UEJ8
      Related
      ENSMUSP00000017597.5, ENSMUST00000017597.5
      Conserved Domains (2) summary
      TIGR01377
      Location:8 → 388
      soxA_mon; sarcosine oxidase, monomeric form
      pfam13450
      Location:12 → 38
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77771440..77784698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248807.1 → XP_011247109.1  peroxisomal sarcosine oxidase isoform X1

      Conserved Domains (1) summary
      TIGR01377
      Location:8 → 374
      soxA_mon; sarcosine oxidase, monomeric form
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D826.1 GenPept UniProtKB/Swiss-Prot:Q9D826

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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