Lcn8 lipocalin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lcn8provided by MGI
Official Full Name: lipocalin 8provided by MGI
Primary source: MGI:MGI:2135945
See related: Ensembl:ENSMUSG00000036449 AllianceGenome:MGI:2135945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP17; Lcn5; mEP17; 9230106L18Rik
Summary: Predicted to enable small molecule binding activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Orthologous to human LCN8 (lipocalin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 2151.2) See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25543130..25546229)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25653118..25656217)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice.
Title: Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice.
Deficiency for Lcn8 causes epididymal sperm maturation defects in mice.
Title: Deficiency for Lcn8 causes epididymal sperm maturation defects in mice.
data demonstrate that lipocalin EP17 (mEP17) spatial expression, regulation, and fate are different from that of the highly related mouse epididymal retinoic acid binding protein
Title: Identification, immunolocalization, regulation, and postnatal development of the lipocalin EP17 (epididymal protein of 17 kilodaltons) in the mouse and rat epididymis.
results suggest that the 5.3mEP17(murine epididymal protein of 17 kilodaltons) fragment contains all the information required for spatial and temporal expression in the mouse epididymis
Title: The 5'-flanking region of the murine epididymal protein of 17 kilodaltons gene targets transgene expression in the epididymis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: epididymal-specific lipocalin-8

Names: epididymal 17 kDa lipocalin; lipocalin 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033145.1 → NP_149157.1 epididymal-specific lipocalin-8 precursor

See identical proteins and their annotated locations for NP_149157.1

Status: VALIDATED

Source sequence(s)

AF082221

Consensus CDS

CCDS15786.1

UniProtKB/Swiss-Prot

Q924P3

Related

ENSMUSP00000043902.7, ENSMUST00000038482.7

Conserved Domains (1) summary

pfam00061
Location:33 → 157

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family