Stau1 staufen double-stranded RNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stau1provided by MGI
Official Full Name: staufen double-stranded RNA binding protein 1provided by MGI
Primary source: MGI:MGI:1338864
See related: Ensembl:ENSMUSG00000039536 AllianceGenome:MGI:1338864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stau; 5830401L18Rik
Summary: Enables RNA binding activity. Involved in dendritic transport of messenger ribonucleoprotein complex. Acts upstream of or within intracellular mRNA localization. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; gonad; and sensory organ. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 16.8), adrenal adult (RPKM 16.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.22 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (166789469..166838253, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (166947549..166996315, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STAU1 promotes adipogenesis by regulating the alternative splicing of Ppargamma2 mRNA.
Title: STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA.
Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.
Title: Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.
Staufen1 unwinds the secondary structure and facilitates the translation of fatty acid binding protein 4 mRNA during adipogenesis.
Title: Staufen1 unwinds the secondary structure and facilitates the translation of fatty acid binding protein 4 mRNA during adipogenesis.
Staufen 1 amplifies proapoptotic activation of the unfolded protein response.
Title: Staufen 1 amplifies proapoptotic activation of the unfolded protein response.
Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features.
Title: Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features.
Staufen1 in Human Neurodegeneration.
Title: Staufen1 in Human Neurodegeneration.
haploinsufficiency partially restored behavioral, proteomic, and morphological characteristics of spinocerebellar ataxia type 2 pathology in vivo
Title: Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5/Stau1 axis during mammalian corticogenesis.
Title: Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.
we suggest a model in which dynein's interaction with Staufen1 regulates mRNA localization along the axon and the synapses, and alterations in this process may correlate with synapse disruption and amyotrophic lateral sclerosis toxicity.
Title: Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.
Collectively our results show that Staufen1 is highly expressed during early stages of differentiation/development and that it can impair differentiation by regulating c-myc thereby highlighting the multifunctional role of Staufen1 in skeletal muscle cell
Title: The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc-dependent mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548143

Stau1 (e-PCR), detects polymorphism
- UniSTS:479282

AW549911 (e-PCR)
- UniSTS:178773

RH127232 (e-PCR)
- UniSTS:207446

Stau1 (e-PCR), detects polymorphism
- UniSTS:547730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic transport of messenger ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic transport of messenger ribonucleoprotein complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular mRNA localization	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by virus of viral protein levels in host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 1

Names: staufen (RNA binding protein) homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109905.2 → NP_001103375.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 2

See identical proteins and their annotated locations for NP_001103375.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AK005002, AK139532, AL591711, BQ032760, BU757992

Consensus CDS

CCDS50800.1

UniProtKB/TrEMBL

Q3U8D3, Q9DBE7

Related

ENSMUSP00000104858.2, ENSMUST00000109235.8

Conserved Domains (3) summary

smart00358
Location:98 → 161

DSRM; Double-stranded RNA binding motif

cd00048
Location:198 → 264

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:360 → 469

Staufen_C; Staufen C-terminal domain
NM_001109906.2 → NP_001103376.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK139532, AK160979, AL591711, BQ032760, BU757992

Consensus CDS

CCDS50801.1

UniProtKB/TrEMBL

A2A5S3, Q3U8D3

Related

ENSMUSP00000104861.3, ENSMUST00000109238.9

Conserved Domains (3) summary

smart00358
Location:98 → 167

DSRM; Double-stranded RNA binding motif

cd00048
Location:204 → 270

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:366 → 475

Staufen_C; Staufen C-terminal domain
NM_001291160.1 → NP_001278089.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and contains an alternate exon that results in a shorter 3' coding region and an additional segment in the 3' UTR, compared to variant 1. The encoded isoform (4) is shorter at the C-terminus, compared to isoform 1.

Source sequence(s)

AK139532, AK151835, AL591711, BQ032760, BU757992

Consensus CDS

CCDS71197.1

UniProtKB/TrEMBL

A2A5R8, Q3U7A6

Related

ENSMUSP00000042626.6, ENSMUST00000049412.12

Conserved Domains (3) summary

pfam16482
Location:360 → 469

Staufen_C; Staufen C-terminal domain

cd19885
Location:188 → 273

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:95 → 161

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_011490.4 → NP_035620.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 3

See identical proteins and their annotated locations for NP_035620.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

AK139532, AK145826, AK159781, AL591711, BQ032760, BU757992

Consensus CDS

CCDS17093.1

UniProtKB/Swiss-Prot

Q9Z108

UniProtKB/TrEMBL

Q3U8D3

Related

ENSMUSP00000104859.3, ENSMUST00000109236.9

Conserved Domains (3) summary

smart00358
Location:98 → 161

DSRM; Double-stranded RNA binding motif

cd00048
Location:196 → 262

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:358 → 467

Staufen_C; Staufen C-terminal domain

RNA

NR_111895.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) is shorter in the 5' region and lacks an internal segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK139532, AK160979, AL591711, AY391773, BQ032760, BU757992

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

166789469..166838253 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160105.1 → XP_036015998.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/TrEMBL

A2A5R8, Q3U7A6

Conserved Domains (3) summary

pfam16482
Location:360 → 469

Staufen_C; Staufen C-terminal domain

cd19885
Location:188 → 273

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:95 → 161

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_006499071.3 → XP_006499134.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006499134.1

UniProtKB/TrEMBL

Q3U7A6

Related

ENSMUSP00000139039.2, ENSMUST00000184390.2

Conserved Domains (3) summary

pfam16482
Location:366 → 475

Staufen_C; Staufen C-terminal domain

cd19885
Location:194 → 279

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:95 → 167

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_006499072.3 → XP_006499135.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006499135.1

UniProtKB/TrEMBL

Q3U7A6

Conserved Domains (3) summary

pfam16482
Location:366 → 475

Staufen_C; Staufen C-terminal domain

cd19885
Location:194 → 279

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:95 → 167

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_030249042.1 → XP_030104902.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X4

UniProtKB/TrEMBL

Q3U8D3

Conserved Domains (3) summary

pfam16482
Location:311 → 420

Staufen_C; Staufen C-terminal domain

cd19883
Location:95 → 161

DSRM_STAU1_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:1 → 70

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_011239406.1 → XP_011237708.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X3

UniProtKB/TrEMBL

Q3U8D3

Conserved Domains (2) summary

pfam16482
Location:317 → 426

Staufen_C; Staufen C-terminal domain

cl00054
Location:95 → 167

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily