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    Rell1 RELT-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 100532, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rell1provided by MGI
    Official Full Name
    RELT-like 1provided by MGI
    Primary source
    MGI:MGI:2140767
    See related
    Ensembl:ENSMUSG00000047881 AllianceGenome:MGI:2140767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in positive regulation of p38MAPK cascade. Predicted to be located in microtubule cytoskeleton. Predicted to be active in plasma membrane. Is expressed in retina. Orthologous to human RELL1 (RELT like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.9), adrenal adult (RPKM 7.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.1; 5 32.8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64047296..64126165, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (63889337..63969020, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13178 Neighboring gene NACHT and WD repeat domain containing 2, opposite strand Neighboring gene NACHT and WD repeat domain containing 2 Neighboring gene hematological and neurological expressed 1 protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_13179 Neighboring gene RIKEN cDNA 0610040J01 gene Neighboring gene STARR-positive B cell enhancer ABC_E8053 Neighboring gene STARR-seq mESC enhancer starr_13182 Neighboring gene STARR-seq mESC enhancer starr_13187 Neighboring gene STARR-positive B cell enhancer ABC_E8054 Neighboring gene STARR-seq mESC enhancer starr_13191 Neighboring gene STARR-seq mESC enhancer starr_13192 Neighboring gene STARR-seq mESC enhancer starr_13193 Neighboring gene predicted gene, 25608 Neighboring gene RIKEN cDNA 5830416I19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr5:64431930-64432231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages. Feng L, et al. Tuberculosis (Edinb), 2020 Jan. PMID 32090861
    2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages.
      Title: RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RELT-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417949.1 → NP_001404878.1  RELT-like protein 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC158789
      UniProtKB/Swiss-Prot
      Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5

    2. NM_001417950.1 → NP_001404879.1  RELT-like protein 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC158789
      UniProtKB/Swiss-Prot
      Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5

    3. NM_001417951.1 → NP_001404880.1  RELT-like protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158789

    4. NM_145923.5 → NP_666035.2  RELT-like protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_666035.2

      Status: VALIDATED

      Source sequence(s)
      AC158789
      Consensus CDS
      CCDS39093.1
      UniProtKB/Swiss-Prot
      Q3TVW8, Q3UZH6, Q8K2J7, Q8R3S5
      Related
      ENSMUSP00000118125.2, ENSMUST00000154169.4
      Conserved Domains (1) summary
      pfam12606
      Location:59 → 91
      RELT; tumor necrosis factor receptor superfamily member 19

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      64047296..64126165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2J7.2 GenPept UniProtKB/Swiss-Prot:Q8K2J7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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