Fndc5 fibronectin type III domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fndc5provided by MGI
Official Full Name: fibronectin type III domain containing 5provided by MGI
Primary source: MGI:MGI:1917614
See related: Ensembl:ENSMUSG00000001334 AllianceGenome:MGI:1917614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PeP; Pxp; 1500001L03Rik
Summary: This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]
Expression: Biased expression in heart adult (RPKM 86.3), cerebellum adult (RPKM 47.9) and 6 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 D2.2; 4 62.93 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129030672..129038386)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129136870..129144593)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress-mediated ferroptosis.
Title: FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis.
Exercise enhances placental labyrinth trophoblast development by activation of PGC-1alpha and FNDC5/irisindagger.
Title: Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.
The integrated analysis and underlying mechanisms of FNDC5 on diabetic induced cognitive deficits.
Title: The integrated analysis and underlying mechanisms of FNDC5 on diabetic induced cognitive deficits.
Explore novel molecular mechanisms of FNDC5 in ischemia-reperfusion (I/R) injury by analyzing transcriptome changes in mouse model of skeletal muscle I/R injury with FNDC5 knockout.
Title: Explore novel molecular mechanisms of FNDC5 in ischemia-reperfusion (I/R) injury by analyzing transcriptome changes in mouse model of skeletal muscle I/R injury with FNDC5 knockout.
Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice.
Title: Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice.
FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARalpha/HO-1 in ApoE-/- Mice.
Title: FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARα/HO-1 in ApoE-/- Mice.
Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARgamma and Nrf2 signaling.
Title: Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling.
Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease.
Title: Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Title: FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing.
Title: Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:235039

C87088 (e-PCR)
- UniSTS:207181

Fndc5 (e-PCR), detects polymorphism
- UniSTS:547982

AI836596 (e-PCR)
- UniSTS:164260

NoName (e-PCR)
- UniSTS:488665

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of brown fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: fibronectin type III domain-containing protein 5

Names: fibronectin type III repeat-containing protein 2; peroxisomal protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027402.4 → NP_081678.1 fibronectin type III domain-containing protein 5 preproprotein

See identical proteins and their annotated locations for NP_081678.1

Status: REVIEWED

Source sequence(s)

AA003587, AI836596, AK005096, AL606977, BE861837, BG088140, BY265316, CX207206

Consensus CDS

CCDS18683.1

UniProtKB/Swiss-Prot

Q8K4Z2, Q9DB97

Related

ENSMUSP00000099660.4, ENSMUST00000102600.4

Conserved Domains (2) summary

cd00063
Location:31 → 121

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:148 → 181

DUF4808; Domain of unknown function (DUF4808)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

129030672..129038386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503212.5 → XP_006503275.1 fibronectin type III domain-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006503275.1

Conserved Domains (1) summary

cd00063
Location:62 → 152

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...