Slc39a14 solute carrier family 39 (zinc transporter), member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a14provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 14provided by MGI
Primary source: MGI:MGI:2384851
See related: Ensembl:ENSMUSG00000022094 AllianceGenome:MGI:2384851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip14; ZIP-14; fad123; FAD-123
Summary: Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including negative regulation of cyclic-nucleotide phosphodiesterase activity; transition metal ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in autopod; ear; face; nervous system; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 12.6), liver E18 (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.32 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70540916..70588873, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70303467..70351452, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia.
Title: Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia.
Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism.
Title: Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism.
Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression.
Title: Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression.
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms.
Title: Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms.
Long Noncoding RNA, MicroRNA, Zn Transporter Zip14 (Slc39a14) and Inflammation in Mice.
Title: Long Noncoding RNA, MicroRNA, Zn Transporter Zip14 (Slc39a14) and Inflammation in Mice.
Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice.
Title: Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice.
Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.
Title: Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.
Restriction of Manganese Intake Prevents the Onset of Brain Manganese Overload in Zip14(-/-) Mice.
Title: Restriction of Manganese Intake Prevents the Onset of Brain Manganese Overload in Zip14(-/-) Mice.
Aberrant Zip14 expression in muscle is associated with cachexia in a Bard1-deficient mouse model of breast cancer metastasis.
Title: Aberrant Zip14 expression in muscle is associated with cachexia in a Bard1-deficient mouse model of breast cancer metastasis.
This study provides evidence in an integrative animal model that basolaterally localized ZIP14 regulates Mn excretion and detoxification and that deletion of intestinal ZIP14 leads to systemic and brain Mn accumulation, providing robust evidence for the indispensable role of intestinal ZIP14 in Mn excretion.
Title: Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc39a14 (e-PCR), detects polymorphism
- UniSTS:547104

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables iron ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic anion:monoatomic cation symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in manganese ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cyclic-nucleotide phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of hormone levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal cation symporter ZIP14

Names: Zrt- and Irt-like protein 14; factor for adipocyte differentiation 123; zinc transporter ZIP14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135151.1 → NP_001128623.1 metal cation symporter ZIP14 isoform a precursor

See identical proteins and their annotated locations for NP_001128623.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AC025669

Consensus CDS

CCDS49536.1

UniProtKB/Swiss-Prot

Q75N73

UniProtKB/TrEMBL

A0A0R4J1V1

Related

ENSMUSP00000022688.4, ENSMUST00000022688.10

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter
NM_001135152.1 → NP_001128624.1 metal cation symporter ZIP14 isoform a precursor

See identical proteins and their annotated locations for NP_001128624.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC025669, AK050076, AK090193

Consensus CDS

CCDS49536.1

UniProtKB/Swiss-Prot

Q75N73

UniProtKB/TrEMBL

A0A0R4J1V1

Related

ENSMUSP00000119040.2, ENSMUST00000152067.8

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter
NM_144808.4 → NP_659057.2 metal cation symporter ZIP14 isoform b precursor

See identical proteins and their annotated locations for NP_659057.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is the same length as isoform a, but contains a distinct internal segment.

Source sequence(s)

AC025669, AK090193, AK158096, BY253316, CB521415

Consensus CDS

CCDS36969.1

UniProtKB/Swiss-Prot

A0A0R4J1V1, Q75N73, Q80U85, Q8VDL0

Related

ENSMUSP00000066108.8, ENSMUST00000068044.14

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70540916..70588873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247713.2 → XP_030103573.1 metal cation symporter ZIP14 isoform X5

UniProtKB/Swiss-Prot

A0A0R4J1V1, Q75N73, Q80U85, Q8VDL0

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter
XM_006518786.5 → XP_006518849.1 metal cation symporter ZIP14 isoform X2

Conserved Domains (1) summary

pfam02535
Location:202 → 532

Zip; ZIP Zinc transporter
XM_006518787.5 → XP_006518850.1 metal cation symporter ZIP14 isoform X3

Conserved Domains (1) summary

pfam02535
Location:202 → 523

Zip; ZIP Zinc transporter
XM_030247712.2 → XP_030103572.1 metal cation symporter ZIP14 isoform X1

Conserved Domains (1) summary

pfam02535
Location:202 → 532

Zip; ZIP Zinc transporter
XM_030247714.1 → XP_030103574.1 metal cation symporter ZIP14 isoform X6

Conserved Domains (1) summary

pfam02535
Location:6 → 313

Zip; ZIP Zinc transporter
XM_030247717.1 → XP_030103577.1 metal cation symporter ZIP14 isoform X6

Conserved Domains (1) summary

pfam02535
Location:6 → 313

Zip; ZIP Zinc transporter
XM_006518789.3 → XP_006518852.1 metal cation symporter ZIP14 isoform X4

See identical proteins and their annotated locations for XP_006518852.1

UniProtKB/Swiss-Prot

Q75N73

UniProtKB/TrEMBL

A0A0R4J1V1

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter
XM_030247715.1 → XP_030103575.1 metal cation symporter ZIP14 isoform X6

Conserved Domains (1) summary

pfam02535
Location:6 → 313

Zip; ZIP Zinc transporter
XM_006518788.3 → XP_006518851.1 metal cation symporter ZIP14 isoform X4

See identical proteins and their annotated locations for XP_006518851.1

UniProtKB/Swiss-Prot

Q75N73

UniProtKB/TrEMBL

A0A0R4J1V1

Conserved Domains (1) summary

pfam02535
Location:150 → 480

Zip; ZIP Zinc transporter
XM_030247716.1 → XP_030103576.1 metal cation symporter ZIP14 isoform X6

Conserved Domains (1) summary

pfam02535
Location:6 → 313

Zip; ZIP Zinc transporter
XM_006518791.1 → XP_006518854.1 metal cation symporter ZIP14 isoform X6

Conserved Domains (1) summary

pfam02535
Location:6 → 313

Zip; ZIP Zinc transporter