Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnq2provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily Q, member 2provided by MGI
Primary source: MGI:MGI:1309503
See related: Ensembl:ENSMUSG00000016346 AllianceGenome:MGI:1309503
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KQT2; HNSPC; Nmf134
Summary: Enables calmodulin binding activity and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and transmission of nerve impulse. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including brain; gut; immune system; reproductive system; and white fat. Used to study benign neonatal seizures and developmental and epileptic encephalopathy 7. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 26.0), frontal lobe adult (RPKM 26.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.57 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180717372..180777368, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181075579..181135580, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models.
Title: Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models.
KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.
Title: KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Title: Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Mouse models of Kcnq2 dysfunction.
Title: Mouse models of Kcnq2 dysfunction.
Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.
Title: Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.
Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
Title: Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior.
Title: Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior.
Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
Title: Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
Title: KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.
Title: Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:143684 (e-PCR)
- UniSTS:143684

Kcnq2 (e-PCR), detects polymorphism
- UniSTS:143684

AB000494 (e-PCR)
- UniSTS:178797

UniSTS:495992 (e-PCR)
- UniSTS:495992

Kcnq2 (e-PCR), detects polymorphism
- UniSTS:495992

D2Frk1 (e-PCR), detects polymorphism
- UniSTS:243362

Kcnq2 (e-PCR), detects polymorphism
- UniSTS:259498

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within action potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within action potential initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within action potential initiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within action potential initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within excitatory chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampal pyramidal neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inhibitory chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nerve development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within psychomotor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of action potential firing threshold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to auditory stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within substantia propria of cornea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 2

Names: KQT-like 2; potassium channel subunit alpha KvLQT2; voltage-gated potassium channel subunit Kv7.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003824.2 → NP_001003824.1 potassium voltage-gated channel subfamily KQT member 2 isoform 2

See identical proteins and their annotated locations for NP_001003824.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons but includes an additional in-frame exon, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL450341, BC145453, CJ121810, CJ263767

Consensus CDS

CCDS17193.1

UniProtKB/Swiss-Prot

Q3UTI0, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350, Q9Z351

UniProtKB/TrEMBL

B7ZBV4

Related

ENSMUSP00000016491.8, ENSMUST00000016491.14

Conserved Domains (4) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 666

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam16642
Location:675 → 754

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
NM_001003825.3 → NP_001003825.1 potassium voltage-gated channel subfamily KQT member 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL450341, CJ119072, CJ121810, CJ263767

Consensus CDS

CCDS17194.1

UniProtKB/Swiss-Prot

Q3UTI0, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350, Q9Z351

UniProtKB/TrEMBL

B7ZBV6

Related

ENSMUSP00000052453.9, ENSMUST00000049792.15

Conserved Domains (4) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 661

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam16642
Location:670 → 749

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
NM_001006668.2 → NP_001006669.1 potassium voltage-gated channel subfamily KQT member 2 isoform 4

See identical proteins and their annotated locations for NP_001006669.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons but includes an additional in-frame exon, it uses an alternate in-frame splice site, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL450341, CJ119072, CJ121810, CJ263767

Consensus CDS

CCDS17195.1

UniProtKB/Swiss-Prot

Q3UTI0, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350, Q9Z351

UniProtKB/TrEMBL

B7ZBV8

Related

ENSMUSP00000099336.4, ENSMUST00000103047.10

Conserved Domains (4) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:432 → 654

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam16642
Location:663 → 742

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
NM_001006669.2 → NP_001006670.1 potassium voltage-gated channel subfamily KQT member 2 isoform 5

See identical proteins and their annotated locations for NP_001006670.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL450341, CJ119072, CJ121810, CJ263767

Consensus CDS

CCDS17196.1

UniProtKB/Swiss-Prot

Q3UTI0, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350, Q9Z351

UniProtKB/TrEMBL

B7ZBV7

Related

ENSMUSP00000099337.4, ENSMUST00000103048.10

Conserved Domains (4) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 630

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam16642
Location:639 → 718

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
NM_001006674.2 → NP_001006675.1 potassium voltage-gated channel subfamily KQT member 2 isoform 6

See identical proteins and their annotated locations for NP_001006675.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL450341, CJ119072, CJ121810, CJ263767

Consensus CDS

CCDS17197.1

UniProtKB/TrEMBL

B7ZBV5

Related

ENSMUSP00000080243.7, ENSMUST00000081528.13

Conserved Domains (3) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 561

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel
NM_001302888.1 → NP_001289817.1 potassium voltage-gated channel subfamily KQT member 2 isoform 13

Status: VALIDATED

Description

Transcript Variant: This variant (13) lacks an alternate in-frame exon and uses an alternate in-frame splice site, resulting in an isoform (13) that is shorter than isoform 1.

Source sequence(s)

AK139411, AL450341, CJ119072, CJ121810, CJ263767

UniProtKB/TrEMBL

F6UC55

Related

ENSMUSP00000099338.4, ENSMUST00000103049.10

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:454 → 639

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:757 → 847

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:648 → 735

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
NM_001420340.1 → NP_001407269.1 potassium voltage-gated channel subfamily KQT member 2 isoform 7

Status: VALIDATED

Source sequence(s)

AL450341
NM_001420341.1 → NP_001407270.1 potassium voltage-gated channel subfamily KQT member 2 isoform 14

Status: VALIDATED

Source sequence(s)

AL450341
NM_001420342.1 → NP_001407271.1 potassium voltage-gated channel subfamily KQT member 2 isoform 15

Status: VALIDATED

Source sequence(s)

AL450341
NM_010611.3 → NP_034741.2 potassium voltage-gated channel subfamily KQT member 2 isoform 1

See identical proteins and their annotated locations for NP_034741.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK135059, AK139411, AL450341, CJ119072, CJ121810, CJ125938, CJ263767

Consensus CDS

CCDS17198.1

UniProtKB/TrEMBL

B7ZBV9, F6UC55

Related

ENSMUSP00000122915.3, ENSMUST00000149964.9

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:472 → 658

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:776 → 866

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:667 → 754

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180717372..180777368 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315767.3 → XP_017171256.1 potassium voltage-gated channel subfamily KQT member 2 isoform X24

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:426 → 612

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:733 → 826

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:627 → 714

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315754.3 → XP_017171243.1 potassium voltage-gated channel subfamily KQT member 2 isoform X17

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:426 → 648

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:769 → 862

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:663 → 750

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247788.2 → XP_030103648.1 potassium voltage-gated channel subfamily KQT member 2 isoform X21

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 623

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:744 → 837

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:638 → 725

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247775.2 → XP_030103635.1 potassium voltage-gated channel subfamily KQT member 2 isoform X9

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 690

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:811 → 904

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:705 → 792

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_006500567.3 → XP_006500630.1 potassium voltage-gated channel subfamily KQT member 2 isoform X20

UniProtKB/TrEMBL

A0A0G2JFQ2, F6UC55

Related

ENSMUSP00000143263.2, ENSMUST00000197015.5

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 624

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:745 → 838

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:639 → 726

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315747.3 → XP_017171236.1 potassium voltage-gated channel subfamily KQT member 2 isoform X14

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 660

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:781 → 874

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:675 → 762

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315751.3 → XP_017171240.1 potassium voltage-gated channel subfamily KQT member 2 isoform X15

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 655

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:776 → 869

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:670 → 757

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315743.3 → XP_017171232.1 potassium voltage-gated channel subfamily KQT member 2 isoform X8

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 691

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:812 → 905

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:706 → 793

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_036158776.1 → XP_036014669.1 potassium voltage-gated channel subfamily KQT member 2 isoform X18

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:456 → 641

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:755 → 855

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:656 → 743

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247769.2 → XP_030103629.1 potassium voltage-gated channel subfamily KQT member 2 isoform X4

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:456 → 708

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:829 → 922

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:723 → 810

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315740.3 → XP_017171229.1 potassium voltage-gated channel subfamily KQT member 2 isoform X3

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:456 → 709

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:830 → 923

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:724 → 811

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_006500568.3 → XP_006500631.1 potassium voltage-gated channel subfamily KQT member 2 isoform X23

UniProtKB/TrEMBL

B7ZBW2, F6UC55

Related

ENSMUSP00000099339.5, ENSMUST00000103050.10

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:436 → 621

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:742 → 835

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:636 → 723

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315763.3 → XP_017171252.1 potassium voltage-gated channel subfamily KQT member 2 isoform X22

UniProtKB/TrEMBL

F6UC55

Related

ENSMUSP00000123488.2, ENSMUST00000129695.8

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:436 → 622

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:743 → 836

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:637 → 724

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315744.3 → XP_017171233.1 potassium voltage-gated channel subfamily KQT member 2 isoform X10

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:436 → 689

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:810 → 903

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:704 → 791

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247772.2 → XP_030103632.1 potassium voltage-gated channel subfamily KQT member 2 isoform X7

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 700

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:821 → 914

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:715 → 802

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_006500565.3 → XP_006500628.1 potassium voltage-gated channel subfamily KQT member 2 isoform X19

UniProtKB/TrEMBL

B7ZBW1, F6UC55

Related

ENSMUSP00000099340.3, ENSMUST00000103051.9

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 634

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:755 → 848

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:649 → 736

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_036158772.1 → XP_036014665.1 potassium voltage-gated channel subfamily KQT member 2 isoform X13

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 670

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:784 → 884

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:685 → 772

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315742.3 → XP_017171231.1 potassium voltage-gated channel subfamily KQT member 2 isoform X6

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 701

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:822 → 915

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:716 → 803

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315741.3 → XP_017171230.1 potassium voltage-gated channel subfamily KQT member 2 isoform X5

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:454 → 707

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:828 → 921

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:722 → 809

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315753.3 → XP_017171242.1 potassium voltage-gated channel subfamily KQT member 2 isoform X16

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 651

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:772 → 865

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:666 → 753

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315738.3 → XP_017171227.1 potassium voltage-gated channel subfamily KQT member 2 isoform X2

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 718

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:839 → 932

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:733 → 820

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_011239925.3 → XP_011238227.1 potassium voltage-gated channel subfamily KQT member 2 isoform X11

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 688

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:809 → 902

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:703 → 790

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315746.3 → XP_017171235.1 potassium voltage-gated channel subfamily KQT member 2 isoform X12

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 683

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:804 → 897

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:698 → 785

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315735.3 → XP_017171224.1 potassium voltage-gated channel subfamily KQT member 2 isoform X1

UniProtKB/TrEMBL

F6UC55

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 719

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:840 → 933

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:734 → 821

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247798.2 → XP_030103658.1 potassium voltage-gated channel subfamily KQT member 2 isoform X26

UniProtKB/TrEMBL

B7ZBV3

Conserved Domains (4) summary

pfam00520
Location:1 → 151

Ion_trans; Ion transport protein

pfam03520
Location:265 → 518

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:639 → 732

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:533 → 620

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_036158780.1 → XP_036014673.1 potassium voltage-gated channel subfamily KQT member 2 isoform X27

Conserved Domains (3) summary

pfam03520
Location:17 → 270

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:384 → 484

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:285 → 372

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_030247797.1 → XP_030103657.1 potassium voltage-gated channel subfamily KQT member 2 isoform X25

UniProtKB/TrEMBL

B7ZBV3

Conserved Domains (4) summary

pfam00520
Location:1 → 151

Ion_trans; Ion transport protein

pfam03520
Location:293 → 546

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:667 → 760

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:561 → 648

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315771.3 → XP_017171260.1 potassium voltage-gated channel subfamily KQT member 2 isoform X27

Conserved Domains (3) summary

pfam03520
Location:17 → 270

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:384 → 484

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:285 → 372

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315781.3 → XP_017171270.1 potassium voltage-gated channel subfamily KQT member 2 isoform X28

Conserved Domains (3) summary

pfam03520
Location:17 → 269

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:390 → 483

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:284 → 371

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315772.3 → XP_017171261.1 potassium voltage-gated channel subfamily KQT member 2 isoform X27

Conserved Domains (3) summary

pfam03520
Location:17 → 270

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:384 → 484

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:285 → 372

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315776.3 → XP_017171265.1 potassium voltage-gated channel subfamily KQT member 2 isoform X27

Conserved Domains (3) summary

pfam03520
Location:17 → 270

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:384 → 484

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:285 → 372

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017315773.3 → XP_017171262.1 potassium voltage-gated channel subfamily KQT member 2 isoform X27

Conserved Domains (3) summary

pfam03520
Location:17 → 270

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:384 → 484

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:285 → 372

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RNA

XR_003950848.2 RNA Sequence
XR_004938437.1 RNA Sequence
XR_004938426.1 RNA Sequence
XR_004938432.1 RNA Sequence
XR_001781086.3 RNA Sequence
XR_001781085.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001006675.1: Suppressed sequence

Description

NM_001006675.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
NM_001006676.1: Suppressed sequence

Description

NM_001006676.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
NM_001006677.1: Suppressed sequence

Description

NM_001006677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
NM_001006678.1: Suppressed sequence

Description

NM_001006678.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incomplete at the 3' end.
NM_001006679.1: Suppressed sequence

Description

NM_001006679.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
NM_001006680.1: Suppressed sequence

Description

NM_001006680.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.