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    LCLAT1 lysocardiolipin acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 253558, updated on 3-Apr-2024

    Summary

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    Official Symbol
    LCLAT1provided by HGNC
    Official Full Name
    lysocardiolipin acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:26756
    See related
    Ensembl:ENSG00000172954 MIM:614241; AllianceGenome:HGNC:26756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849
    Summary
    Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30447246..30644225)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30491581..30688529)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30670112..30867091)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15536 Neighboring gene uncharacterized LOC102723594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15537 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30517185-30517355 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30523745-30524427 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30524428-30525109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30525110-30525792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30525793-30526473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15543 Neighboring gene long intergenic non-protein coding RNA 1936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30633050-30633962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30666124-30666624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30669802-30670539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30670540-30671276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30738762-30739262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30739263-30739763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:30835819-30836816 Neighboring gene MPRA-validated peak3643 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15548 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:30874941-30875672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30875673-30876403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11329 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30943850-30944350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30944351-30944851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30988245-30988745 Neighboring gene calpain 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020137-31020846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020847-31021554 Neighboring gene uncharacterized LOC124905982 Neighboring gene uncharacterized LOC105374435

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics. Huang LS, et al. J Biol Chem, 2020 Sep 18. PMID 32732285, Free PMC Article
    2. The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Huang LS, et al. Am J Respir Crit Care Med, 2014 Jun 1. PMID 24779708, Free PMC Article
    3. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Wang C, et al. Blood, 2007 Nov 15. PMID 17675553, Free PMC Article
    4. Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation. Huang LS, et al. Free Radic Biol Med, 2017 Nov. PMID 28751023
    5. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. Zhao Y, et al. J Lipid Res, 2009 May. PMID 19075029, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
      Title: ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
    2. Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.
      Title: Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.
    3. Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
      Title: Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
    4. LYCAT regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.
      Title: Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.
    5. LYCAT expression was significantly altered in PBMCs and lung tissues from patients with idiopathic pulmonary fibrosis.
      Title: The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
    6. Data show that ALCAT1 possesses acyltransferase activities toward lysophosphatidylinositol and lysophosphatidylglycerol, and identify critical amino acids that are potentially involved in lysophospholipid substrate binding.
      Title: The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    lysocardiolipin acyltransferase 1
    Names
    1-AGP acyltransferase 8
    1-AGPAT 8
    1-acylglycerol-3-phosphate O-acyltransferase 8
    1ysophospholipid acyltransferase 6
    acyl-CoA:lysocardiolipin acyltransferase 1
    NP_001002257.1
    NP_001291374.1
    NP_001291375.1
    NP_872357.2
    XP_005264301.1
    XP_005264302.1
    XP_011531043.1
    XP_016859235.1
    XP_016859236.1
    XP_047299824.1
    XP_047299825.1
    XP_054197237.1
    XP_054197238.1
    XP_054197239.1
    XP_054197240.1
    XP_054197241.1
    XP_054197242.1
    XP_054197243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002257.3 → NP_001002257.1  lysocardiolipin acyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001002257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC132154, BC146817, BX537607
      Consensus CDS
      CCDS42670.1
      UniProtKB/TrEMBL
      B4DYR5
      Related
      ENSP00000368823.3, ENST00000379509.8
      Conserved Domains (3) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7 → 286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234 → 306
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001304445.2 → NP_001291374.1  lysocardiolipin acyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001291374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC073255, AC132154, AK302562, BX537607
      Consensus CDS
      CCDS42670.1
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7 → 286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234 → 306
      Acyltransf_C; Acyltransferase C-terminus

    3. NM_001304446.2 → NP_001291375.1  lysocardiolipin acyltransferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001291375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC132154, AK297262, BX537607
      UniProtKB/TrEMBL
      B4DM26
      Conserved Domains (2) summary
      cd07990
      Location:1 → 124
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:110 → 182
      Acyltransf_C; Acyltransferase C-terminus

    4. NM_182551.5 → NP_872357.2  lysocardiolipin acyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_872357.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC132154, AY358702, BP872689, BX537607
      Consensus CDS
      CCDS1772.1
      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Related
      ENSP00000310551.4, ENST00000309052.8
      Conserved Domains (3) summary
      cd07990
      Location:93 → 286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45 → 324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272 → 344
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      30447246..30644225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264245.4 → XP_005264302.1  lysocardiolipin acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_005264302.1

      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7 → 286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234 → 306
      Acyltransf_C; Acyltransferase C-terminus

    2. XM_005264244.2 → XP_005264301.1  lysocardiolipin acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005264301.1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:93 → 286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45 → 324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272 → 344
      Acyltransf_C; Acyltransferase C-terminus

    3. XM_047443868.1 → XP_047299824.1  lysocardiolipin acyltransferase 1 isoform X2

    4. XM_017003746.2 → XP_016859235.1  lysocardiolipin acyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7 → 286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234 → 306
      Acyltransf_C; Acyltransferase C-terminus

    5. XM_047443869.1 → XP_047299825.1  lysocardiolipin acyltransferase 1 isoform X3

      Related
      ENSP00000368826.1, ENST00000319406.8

    6. XM_017003747.3 → XP_016859236.1  lysocardiolipin acyltransferase 1 isoform X4

    7. XM_011532741.3 → XP_011531043.1  lysocardiolipin acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011531043.1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:93 → 286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45 → 324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272 → 344
      Acyltransf_C; Acyltransferase C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      30491581..30688529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341268.1 → XP_054197243.1  lysocardiolipin acyltransferase 1 isoform X2

    2. XM_054341262.1 → XP_054197237.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7

    3. XM_054341264.1 → XP_054197239.1  lysocardiolipin acyltransferase 1 isoform X2

    4. XM_054341265.1 → XP_054197240.1  lysocardiolipin acyltransferase 1 isoform X2

    5. XM_054341266.1 → XP_054197241.1  lysocardiolipin acyltransferase 1 isoform X3

    6. XM_054341267.1 → XP_054197242.1  lysocardiolipin acyltransferase 1 isoform X4

    7. XM_054341263.1 → XP_054197238.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWP7.1 GenPept UniProtKB/Swiss-Prot:Q6UWP7

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