Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cideaprovided by MGI
Official Full Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector Aprovided by MGI
Primary source: MGI:MGI:1270845
See related: Ensembl:ENSMUSG00000024526 AllianceGenome:MGI:1270845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of sequestering of triglyceride. Acts upstream of or within lipid metabolic process and response to stilbenoid. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 57.2), subcutaneous fat pad adult (RPKM 43.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 39.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (67476634..67500864)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (67343564..67367794)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.
Title: DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
Title: The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress.
Title: Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress.
our findings suggest that Cidea is highly associated with alcoholic fatty liver disease and Cidea expression is specifically induced by acetaldehyde, and this up-regulation is most likely mediated by SREBP1c.
Title: SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice.
results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes.
Title: Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes.
The authors show demonstrate an essential role of an amphipathic helix in CIDEA, which facilitates embedding in the lipid droplet phospholipid monolayer and binds phosphatidic acid (PA).
Title: The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.
Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.
Title: Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
Cidea is highly associated with adiposity and insulin resistance, whereas Cidec is related to insulin sensitivity
Title: Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice.
data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity
Title: Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue.
maternal diet modulates the age-associated changes in Cidea expression leading to the development of fatty liver
Title: Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cidea (e-PCR), detects polymorphism
- UniSTS:547431

AW212747 (e-PCR)
- UniSTS:181143

40.MMHAP33FRF10.seq (e-PCR)
- UniSTS:124366

AF041376 (e-PCR)
- UniSTS:160758

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lipid droplet	ISO Inferred from Sequence Orthology more info
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lipid transferase CIDEA

Names: cell death activator CIDE-A; cell death-inducing DFFA-like effector A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007702.2 → NP_031728.2 lipid transferase CIDEA

See identical proteins and their annotated locations for NP_031728.2

Status: VALIDATED

Source sequence(s)

BB614324, BQ554476, BQ554477

Consensus CDS

CCDS37846.1

UniProtKB/Swiss-Prot

O70302, Q4V9X2

Related

ENSMUSP00000025404.9, ENSMUST00000025404.10

Conserved Domains (1) summary

cd06539
Location:33 → 110

CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...