Btg2 BTG anti-proliferation factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btg2provided by MGI
Official Full Name: BTG anti-proliferation factor 2provided by MGI
Primary source: MGI:MGI:108384
See related: Ensembl:ENSMUSG00000020423 AllianceGenome:MGI:108384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pc3; APRO1; TIS21
Summary: Predicted to enable transcription corepressor activity. Acts upstream of or within several processes, including associative learning; central nervous system development; and skeletal muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 131.1), spleen adult (RPKM 49.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.1 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134002603..134006893, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134074865..134079155, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis and wound healing in obese mice.
Title: MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis and wound healing in obese mice.
Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3-Dependent Podocyte-Mesenchymal Transition.
Title: Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3-Dependent Podocyte-Mesenchymal Transition.
BTG2 acts as an inducer of muscle stem cell senescence.
Title: BTG2 acts as an inducer of muscle stem cell senescence.
Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest.
Title: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest.
Proper regulation of beta-adrenergic signal requires Btg2 gene for lipolysis and thermogenesis in response to starvation or cold acclimation in female mice.
Title: Proper regulation of β-adrenergic signal requires Btg2 gene for lipolysis and thermogenesis in response to starvation or cold acclimation in female mice.
Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2-YY1 signaling pathway.
Title: Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2-YY1 signaling pathway.
Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation.
Title: Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation.
Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion.
Title: Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion.
B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15.
Title: B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15.
BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence.
Title: mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P12 (e-PCR)
- UniSTS:271371

AW822012 (e-PCR)
- UniSTS:207207

PMC123230P1 (e-PCR)
- UniSTS:270445

AA959598 (e-PCR)
- UniSTS:158853

Btg2 (e-PCR), detects polymorphism
- UniSTS:141196

AA819837 (e-PCR)
- UniSTS:261837

NoName (e-PCR)
- UniSTS:224482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein methylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein BTG2

Names: B cell translocation gene 2, anti-proliferative; BTG family member 2; NGF-inducible protein TIS21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.