Kitl kit ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kitlprovided by MGI
Official Full Name: kit ligandprovided by MGI
Primary source: MGI:MGI:96974
See related: Ensembl:ENSMUSG00000019966 AllianceGenome:MGI:96974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
Summary: Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 2.7), CNS E18 (RPKM 2.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 51.4 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (99851477..99936278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (100015615..100100416)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells.
Title: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells.
Postnatal Expression of Kitl Affects Pigmentation of the Epidermis.
Title: Postnatal Expression of Kitl Affects Pigmentation of the Epidermis.
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.
Title: SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.
Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.
Title: Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.
Sertoli cells are the source of stem cell factor for spermatogenesis.
Title: Sertoli cells are the source of stem cell factor for spermatogenesis.
KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway.
Title: KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway.
KIT ligand protects against both light-induced and genetic photoreceptor degeneration.
Title: KIT ligand protects against both light-induced and genetic photoreceptor degeneration.
adipoq, kitl and osx1 may have a role with regulation of hematopoietic stem and progenitor cells and myeloid progenitors
Title: Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Cholangiocytes, but not hepatocytes, from stem cell factor (SCF) Mismatch Mdr2(-/-) mice have increased SCF expression and secretion. Inhibition of SCF in Mdr2(-/-) mice reduced (i) hepatic damage; (ii) mast cell migration; (iii) histamine and SCF serum levels.
Title: Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2(-/-) mice.
data point to transcription factor NRF2 as a major mediator of oxidized palmitoyl-arachidonoyl-phosphatidylcholine -induced upregulation of SCF. This mechanism may represent one of the facets of pleiotropic action of NRF2 in vascular wall.
Title: Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (126)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (21) 1 citation
Chemically and radiation induced (8) 1 citation
Targeted (6) 1 citation
Radiation induced (14) 1 citation
Chemically induced (ENU) (17) 1 citation
Not Applicable (1)
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kitl (e-PCR), detects polymorphism
- UniSTS:226055

Kitl (e-PCR), detects polymorphism
- UniSTS:265231

Kitl (e-PCR), detects polymorphism
- UniSTS:546835

Kitl (e-PCR), detects polymorphism
- UniSTS:261909

MGF (e-PCR)
- UniSTS:266303

Kitl (e-PCR), detects polymorphism
- UniSTS:498240

Kitl (e-PCR), detects polymorphism
- UniSTS:532304

Kitl (e-PCR), detects polymorphism
- UniSTS:525712

Kitl (e-PCR), detects polymorphism
- UniSTS:496538

Kitl (e-PCR), detects polymorphism
- UniSTS:256948

U44725 (e-PCR)
- UniSTS:185850

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables stem cell factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables stem cell factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within germ cell development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanocyte migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of myeloid leukocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAP kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of melanocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kit ligand

Names: C-kit ligand; Steel factor; cloud gray; grizzle-belly; hematopoietic growth factor KL; mast cell growth factor; stem cell factor

NP_001334085.1

EC 3.2.1.31

NP_038626.1

EC 3.2.1.31

XP_006513377.1

EC 3.2.1.31

XP_006513378.1

EC 3.2.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347156.2 → NP_001334085.1 kit ligand isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct internal amino acid and is shorter than isoform 1.

Source sequence(s)

AC159910

Consensus CDS

CCDS83751.1

UniProtKB/Swiss-Prot

P20826

Related

ENSMUSP00000020129.8, ENSMUST00000020129.8
NM_001428623.1 → NP_001415552.1 kit ligand isoform 3

Status: VALIDATED

Source sequence(s)

AC159910
NM_001428627.1 → NP_001415556.1 kit ligand isoform 4

Status: VALIDATED

Source sequence(s)

AC159910
NM_013598.4 → NP_038626.1 kit ligand isoform 1 precursor

See identical proteins and their annotated locations for NP_038626.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC159910

Consensus CDS

CCDS36046.1

UniProtKB/Swiss-Prot

P20826, P97332, Q3TNJ7, Q62524, Q64222, Q921N5

Related

ENSMUSP00000100920.2, ENSMUST00000105283.9

Conserved Domains (1) summary

pfam02404
Location:1 → 273

SCF; Stem cell factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

99851477..99936278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513314.5 → XP_006513377.1 kit ligand isoform X1

Conserved Domains (1) summary

pfam02404
Location:46 → 313

SCF; Stem cell factor
XM_006513315.4 → XP_006513378.1 kit ligand isoform X2

Conserved Domains (1) summary

pfam02404
Location:46 → 285

SCF; Stem cell factor