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    ALDOA aldolase, fructose-bisphosphate A [ Homo sapiens (human) ]

    Gene ID: 226, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ALDOAprovided by HGNC
    Official Full Name
    aldolase, fructose-bisphosphate Aprovided by HGNC
    Primary source
    HGNC:HGNC:414
    See related
    Ensembl:ENSG00000149925 MIM:103850; AllianceGenome:HGNC:414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALDA; GSD12; HEL-S-87p
    Summary
    This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
    Expression
    Ubiquitous expression in heart (RPKM 290.3), esophagus (RPKM 221.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16p11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30064279..30070420)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30346925..30353065)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30075600..30081741)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit E Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7347 Neighboring gene double C2 domain alpha Neighboring gene chromosome 16 open reading frame 92 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30039801-30040645 Neighboring gene TLC domain containing 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7348 Neighboring gene MPRA-validated peak2562 silencer Neighboring gene uncharaterized LOC112694756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30064875-30065853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30065854-30066831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30076132-30076912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10689 Neighboring gene protein phosphatase 4 catalytic subunit Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30096821-30096985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30101709-30102582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7352 Neighboring gene T-box transcription factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. Fenton KD, et al. Protein Sci, 2022 Feb. PMID 34734672, Free PMC Article
    2. Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis. Li X, et al. Int J Biol Sci, 2021. PMID 33994862, Free PMC Article
    3. Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia. Niu Y, et al. Hepatology, 2021 Sep. PMID 33813748, Free PMC Article
    4. ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway. Luo G, et al. Mol Cell Biochem, 2021 Feb. PMID 33089381
    5. A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A. Cho EJ, et al. SLAS Discov, 2020 Oct. PMID 32462959

    See all (270) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation.
      Title: Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation.
    2. Correlations of ALD, Keap-1, and FoxO4 expression with traditional tumor markers and clinicopathological characteristics in colorectal carcinoma.
      Title: Correlations of ALD, Keap-1, and FoxO4 expression with traditional tumor markers and clinicopathological characteristics in colorectal carcinoma.
    3. The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis.
      Title: The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis.
    4. Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.
      Title: Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.
    5. Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population.
      Title: Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population.
    6. Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.
      Title: Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.
    7. A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.
      Title: A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.
    8. ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway.
      Title: ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway.
    9. A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A.
      Title: A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A.
    10. Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness.
      Title: Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    HNSHA due to aldolase A deficiency
    MedGen: C0272066 OMIM: 611881 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of aldolase A (ALDOA) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human aldolase A, fructose-bisphosphate (ALDOA) at amino acid residues 32-33 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10942, MGC17716, MGC17767

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in I band TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in sperm head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase A
    Names
    aldolase A, fructose-bisphosphate
    epididymis secretory sperm binding protein Li 87p
    fructose-1,6-bisphosphate triosephosphate-lyase
    lung cancer antigen NY-LU-1
    muscle-type aldolase
    NP_001121089.1
    NP_001230106.1
    NP_908930.1
    NP_908932.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008010.1 RefSeqGene

      Range
      17591..22245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1180

    mRNA and Protein(s)

    1. NM_001127617.2 → NP_001121089.1  fructose-bisphosphate aldolase A isoform 1

      See identical proteins and their annotated locations for NP_001121089.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 2, 3, 4, 7, 8, 9, and 10 encode the same isoform (1).
      Source sequence(s)
      BU855133, BX647566, DA899482
      Consensus CDS
      CCDS10668.1
      UniProtKB/Swiss-Prot
      B4DXI7, P04075, Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
      UniProtKB/TrEMBL
      J3KPS3, V9HWN7
      Related
      ENSP00000400452.2, ENST00000412304.6
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    2. NM_001243177.4 → NP_001230106.1  fructose-bisphosphate aldolase A isoform 2

      See identical proteins and their annotated locations for NP_001230106.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (2) is longer at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093512, AK301993, DA138954
      Consensus CDS
      CCDS58450.1
      UniProtKB/TrEMBL
      J3KPS3
      Related
      ENSP00000496166.1, ENST00000642816.3
      Conserved Domains (1) summary
      pfam00274
      Location:69 → 418
      Glycolytic; Fructose-bisphosphate aldolase class-I

    3. NM_184041.5 → NP_908930.1  fructose-bisphosphate aldolase A isoform 1

      See identical proteins and their annotated locations for NP_908930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      BC010660, DA138954
      Consensus CDS
      CCDS10668.1
      UniProtKB/Swiss-Prot
      B4DXI7, P04075, Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
      UniProtKB/TrEMBL
      J3KPS3, V9HWN7
      Related
      ENSP00000494188.2, ENST00000643777.4
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    4. NM_184043.2 → NP_908932.1  fructose-bisphosphate aldolase A isoform 1

      See identical proteins and their annotated locations for NP_908932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 2, 3, 4, 7, 8, 9, and 10 encode the same isoform (1).
      Source sequence(s)
      BC013614, BU855133, CB151262, DA564075
      Consensus CDS
      CCDS10668.1
      UniProtKB/Swiss-Prot
      B4DXI7, P04075, Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
      UniProtKB/TrEMBL
      J3KPS3, V9HWN7
      Related
      ENSP00000455800.2, ENST00000563060.6
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30064279..30070420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30346925..30353065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_000034.3: Suppressed sequence

      Description
      NM_000034.3: This RefSeq was removed because the transcript represents a separate adjacent gene.

    2. NM_001243175.1: Suppressed sequence

      Description
      NM_001243175.1: This RefSeq was permanently suppressed because it contains an upstream ORF that renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

    3. NM_001355562.1: Suppressed sequence

      Description
      NM_001355562.1: This RefSeq was removed because it is now thought that this transcript belongs to a separate upstream gene.

    4. NM_001355563.1: Suppressed sequence

      Description
      NM_001355563.1: This RefSeq was removed because it is now thought that this transcript belongs to a separate upstream gene.

    5. NM_001355564.1: Suppressed sequence

      Description
      NM_001355564.1: This RefSeq was removed because it is now thought that this transcript belongs to a separate upstream gene.

    6. NM_001355565.1: Suppressed sequence

      Description
      NM_001355565.1: This RefSeq was removed because it is now thought that this transcript belongs to a separate upstream gene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04075.2 GenPept UniProtKB/Swiss-Prot:P04075

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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