MARCO macrophage receptor with collagenous structure [Homo sapiens (human)] - Gene

Summary

Official Symbol: MARCOprovided by HGNC
Official Full Name: macrophage receptor with collagenous structureprovided by HGNC
Primary source: HGNC:HGNC:6895
See related: Ensembl:ENSG00000019169 MIM:604870; AllianceGenome:HGNC:6895
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SR-A6; SCARA2
Summary: The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q14.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (118942194..118994660)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (119375479..119427929)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (119699770..119752236)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
Title: Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
Title: Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
Title: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
Title: Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
Title: Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
Title: Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
Title: Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
Title: Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
Title: Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
MARCO is involved in hepatocellular carcinoma (HCC)progression and it can be defined as a novel probable biomarker as well as treatment target for HCC.
Title: Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S1251 (e-PCR)
- UniSTS:149150

RH46911 (e-PCR)
- UniSTS:31215

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables pattern recognition receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: macrophage receptor MARCO

Names: scavenger receptor class A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006770.4 → NP_006761.1 macrophage receptor MARCO

See identical proteins and their annotated locations for NP_006761.1

Status: REVIEWED

Source sequence(s)

AC013457

Consensus CDS

CCDS2124.1

UniProtKB/Swiss-Prot

B4DW79, Q9UEW3, Q9Y5S3

UniProtKB/TrEMBL

B4DLJ6, Q4ZG40

Related

ENSP00000318916.4, ENST00000327097.5

Conserved Domains (2) summary

pfam01391
Location:286 → 344

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:424 → 519

SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

118942194..118994660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011512082.3 → XP_011510384.1 macrophage receptor MARCO isoform X1

See identical proteins and their annotated locations for XP_011510384.1

UniProtKB/Swiss-Prot

B4DW79, Q9UEW3, Q9Y5S3

UniProtKB/TrEMBL

B4DLJ6, Q4ZG40

Conserved Domains (2) summary

pfam01391
Location:286 → 344

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:424 → 519

SR; Scavenger receptor Cys-rich
XM_011512083.4 → XP_011510385.1 macrophage receptor MARCO isoform X2

Conserved Domains (3) summary

pfam01391
Location:165 → 223

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:303 → 398

SR; Scavenger receptor Cys-rich

pfam00530
Location:308 → 398

SRCR; Scavenger receptor cysteine-rich domain
XM_017005171.3 → XP_016860660.1 macrophage receptor MARCO isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

119375479..119427929

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344329.1 → XP_054200304.1 macrophage receptor MARCO isoform X1

UniProtKB/Swiss-Prot

B4DW79, Q9UEW3, Q9Y5S3

UniProtKB/TrEMBL

Q4ZG40
XM_054344330.1 → XP_054200305.1 macrophage receptor MARCO isoform X2
XM_054344331.1 → XP_054200306.1 macrophage receptor MARCO isoform X3