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    PDE8B phosphodiesterase 8B [ Homo sapiens (human) ]

    Gene ID: 8622, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PDE8Bprovided by HGNC
    Official Full Name
    phosphodiesterase 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:8794
    See related
    Ensembl:ENSG00000113231 MIM:603390; AllianceGenome:HGNC:8794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADSD; PPNAD3
    Summary
    The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
    Expression
    Biased expression in thyroid (RPKM 82.4), brain (RPKM 15.1) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE8B in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (77086715..77428256)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77568346..77910865)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76476129..76724081)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16108 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76383973-76384573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76382768-76383369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76383370-76383972 Neighboring gene ZBED3 antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene uncharacterized LOC124901008 Neighboring gene zinc finger BED-type containing 3 Neighboring gene Sharpr-MPRA regulatory region 15273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76468397-76468898 Neighboring gene high mobility group box 1 pseudogene 35 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76618089-76618784 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:76672412-76673040 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76752518-76752693 Neighboring gene uncharacterized LOC124901009 Neighboring gene WD repeat domain 41 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76787603-76788526 Neighboring gene ribosomal protein S2 pseudogene 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders. Ni J, et al. Parkinsonism Relat Disord, 2019 Dec. PMID 31726290
    2. PDE8B mutation is not associated with Parkinson's disease in a Taiwanese population. Fan TS, et al. Neurobiol Aging, 2018 Nov. PMID 29909144
    3. A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration. Azuma R, et al. Mov Disord, 2015 Dec. PMID 26769607
    4. Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women. Yang S, et al. Endocr Res, 2015. PMID 25822812
    5. Frequency and effect on serum TSH of phosphodiesterase 8B (PDE8B) gene polymorphisms in patients with sporadic nonautoimmune subclinical hypothyroidism. Agretti P, et al. J Endocrinol Invest, 2014 Feb. PMID 24497218

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.
      Title: cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.
    2. Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.
      Title: Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.
    3. Study shows that PDE8B may not play a major role in familial and early-onset Parkinson disease without distinctive lesions of the striatum on brain MRI in this Taiwanese population.
      Title: PDE8B mutation is not associated with Parkinson's disease in a Taiwanese population.
    4. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis.
      Title: Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis.
    5. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
      Title: Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).
    6. a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration
      Title: A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration.
    7. Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women.
      Title: Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women.
    8. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism.
      Title: Frequency and effect on serum TSH of phosphodiesterase 8B (PDE8B) gene polymorphisms in patients with sporadic nonautoimmune subclinical hypothyroidism.
    9. rs4704397 is associated with thyroid function, risk of MI, and body height.
      Title: The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction, and body height: the Tromsø study.
    10. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations
      Title: Associations of rs4704397 in phosphodiesterase 8B with thyrotropin and thyroid hormone concentrations.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Autosomal dominant striatal neurodegeneration type 1
    MedGen: C4310808 OMIM: 609161 GeneReviews: Not available
    		Compare labs
    Pigmented nodular adrenocortical disease, primary, 3
    MedGen: C3280094 OMIM: 614190 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    EBI GWAS Catalog
    Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.
    EBI GWAS Catalog
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog
    Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog
    Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of steroid hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in operant conditioning IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
    Names
    3',5' cyclic nucleotide phosphodiesterase 8B
    cell proliferation-inducing gene 22 protein
    NP_001025022.1
    NP_001025023.1
    NP_001025024.1
    NP_001025025.1
    NP_001336677.1
    NP_001336678.1
    NP_001336679.1
    NP_001336680.1
    NP_001336681.1
    NP_001336682.1
    NP_001362991.1
    NP_001362992.1
    NP_001362993.1
    NP_001362994.1
    NP_001362995.1
    NP_001362996.1
    NP_001362997.1
    NP_001362998.1
    NP_001362999.1
    NP_001363000.1
    NP_001363001.1
    NP_001363002.1
    NP_001363003.1
    NP_001363004.1
    NP_001401551.1
    NP_001401552.1
    NP_003710.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023364.2 RefSeqGene

      Range
      35429..253005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029851.4 → NP_001025022.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

      See identical proteins and their annotated locations for NP_001025022.1

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS34192.1
      UniProtKB/Swiss-Prot
      O95263
      UniProtKB/TrEMBL
      B3KN77
      Related
      ENSP00000330428.3, ENST00000346042.7
      Conserved Domains (3) summary
      PHA02597
      Location:158 → 311
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:517 → 764
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase

    2. NM_001029852.4 → NP_001025023.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

      See identical proteins and their annotated locations for NP_001025023.1

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KF457931
      Consensus CDS
      CCDS34190.1
      UniProtKB/Swiss-Prot
      O95263
      UniProtKB/TrEMBL
      B3KN77
      Related
      ENSP00000331336.4, ENST00000333194.8
      Conserved Domains (4) summary
      cd00130
      Location:284 → 376
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:559 → 806
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:279 → 377
      PAS_9; PAS domain

    3. NM_001029853.4 → NP_001025024.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

      See identical proteins and their annotated locations for NP_001025024.1

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS34193.1
      UniProtKB/Swiss-Prot
      O95263
      UniProtKB/TrEMBL
      B3KN77
      Related
      ENSP00000345646.4, ENST00000342343.8
      Conserved Domains (4) summary
      cd00130
      Location:264 → 356
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:594 → 841
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:259 → 357
      PAS_9; PAS domain

    4. NM_001029854.4 → NP_001025025.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

      See identical proteins and their annotated locations for NP_001025025.1

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS34191.1
      UniProtKB/Swiss-Prot
      O95263
      UniProtKB/TrEMBL
      B3KN77
      Related
      ENSP00000345446.3, ENST00000340978.7
      Conserved Domains (2) summary
      pfam00233
      Location:567 → 814
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase

    5. NM_001349748.3 → NP_001336677.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:613 → 860
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:279 → 376
      PAS_9; PAS domain

    6. NM_001349749.3 → NP_001336678.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:635 → 882
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:301 → 398
      PAS_9; PAS domain

    7. NM_001349750.3 → NP_001336679.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (2) summary
      pfam00233
      Location:534 → 781
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:200 → 297
      PAS_9; PAS domain

    8. NM_001349751.3 → NP_001336680.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:613 → 805
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:279 → 376
      PAS_9; PAS domain

    9. NM_001349752.3 → NP_001336681.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      COG2202
      Location:46 → 273
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:512 → 759
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:178 → 275
      PAS_9; PAS domain

    10. NM_001349753.2 → NP_001336682.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS87307.1
      UniProtKB/TrEMBL
      A0A2R8Y4E6
      Conserved Domains (3) summary
      COG2202
      Location:24 → 251
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156 → 253
      PAS_9; PAS domain

    11. NM_001376062.1 → NP_001362991.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      COG2202
      Location:47 → 274
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:513 → 760
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:179 → 276
      PAS_9; PAS domain

    12. NM_001376063.1 → NP_001362992.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (4) summary
      COG2202
      Location:148 → 368
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:611 → 858
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:280 → 374
      PAS_9; PAS domain

    13. NM_001376064.1 → NP_001362993.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (4) summary
      COG2202
      Location:148 → 317
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:564 → 811
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:280 → 333
      PAS_9; PAS domain

    14. NM_001376065.1 → NP_001362994.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      PHA02597
      Location:157 → 310
      30.2; hypothetical protein; Provisional
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:516 → 763
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    15. NM_001376066.1 → NP_001362995.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      COG2202
      Location:27 → 254
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:493 → 740
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:159 → 256
      PAS_9; PAS domain

    16. NM_001376067.1 → NP_001362996.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS87307.1
      UniProtKB/TrEMBL
      A0A2R8Y4E6
      Conserved Domains (3) summary
      COG2202
      Location:24 → 251
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156 → 253
      PAS_9; PAS domain

    17. NM_001376068.1 → NP_001362997.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS87307.1
      UniProtKB/TrEMBL
      A0A2R8Y4E6
      Conserved Domains (3) summary
      COG2202
      Location:24 → 251
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156 → 253
      PAS_9; PAS domain

    18. NM_001376069.1 → NP_001362998.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (1) summary
      pfam00233
      Location:486 → 733
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    19. NM_001376070.1 → NP_001362999.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (1) summary
      pfam00233
      Location:466 → 713
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    20. NM_001376071.1 → NP_001363000.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (1) summary
      pfam00233
      Location:465 → 712
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    21. NM_001376072.1 → NP_001363001.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (3) summary
      COG2202
      Location:47 → 274
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:513 → 705
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:179 → 276
      PAS_9; PAS domain

    22. NM_001376073.1 → NP_001363002.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (2) summary
      PHA02597
      Location:57 → 210
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:416 → 663
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    23. NM_001376074.1 → NP_001363003.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      Conserved Domains (2) summary
      PHA02597
      Location:37 → 190
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:396 → 643
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    24. NM_001376075.1 → NP_001363004.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Conserved Domains (2) summary
      PHA02597
      Location:34 → 187
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:393 → 640
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    25. NM_001414622.1 → NP_001401551.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      UniProtKB/TrEMBL
      A0A2R8Y4E6

    26. NM_001414623.1 → NP_001401552.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC008581, AC010234, AC022422, KC877015, KF457931
      UniProtKB/TrEMBL
      A0A2R8Y4E6

    27. NM_003719.5 → NP_003710.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

      See identical proteins and their annotated locations for NP_003710.1

      Status: REVIEWED

      Source sequence(s)
      AC010234, AC022414, AC022422, KC877015, KF457931
      Consensus CDS
      CCDS4037.1
      UniProtKB/Swiss-Prot
      O95263, Q5J7V7, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2
      Related
      ENSP00000264917.6, ENST00000264917.10
      Conserved Domains (4) summary
      cd00130
      Location:284 → 376
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:614 → 861
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:279 → 377
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      77086715..77428256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      77568346..77910865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95263.2 GenPept UniProtKB/Swiss-Prot:O95263

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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