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    Mrpl1 mitochondrial ribosomal protein L1 [ Mus musculus (house mouse) ]

    Gene ID: 94061, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl1provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L1provided by MGI
    Primary source
    MGI:MGI:2137202
    See related
    Ensembl:ENSMUSG00000029486 AllianceGenome:MGI:2137202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L1mt; 2410002L03Rik; 5830418D04Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL1 (mitochondrial ribosomal protein L1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.0), liver E14 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl1 in Genome Data Viewer
    Location:
    5 E3; 5 47.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96357357..96414586)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96209498..96266727)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13673 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene CCR4-NOT transcription complex, subunit 6-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:96589986-96590095 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96592485-96592786 Neighboring gene STARR-positive B cell enhancer ABC_E2159 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96638970-96639271 Neighboring gene STARR-positive B cell enhancer ABC_E10331 Neighboring gene STARR-positive B cell enhancer ABC_E6348 Neighboring gene STARR-seq mESC enhancer starr_13674 Neighboring gene STARR-seq mESC enhancer starr_13675 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050 Neighboring gene predicted gene, 52781

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
    2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL1m
    Names
    39S ribosomal protein L1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039084.1 → NP_001034173.1  large ribosomal subunit protein uL1m isoform 2

      See identical proteins and their annotated locations for NP_001034173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK017938, BX527348
      Consensus CDS
      CCDS51567.1
      UniProtKB/TrEMBL
      Q9D3F3
      Related
      ENSMUSP00000112451.2, ENSMUST00000121477.2
      Conserved Domains (1) summary
      cl00322
      Location:102 → 244
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    2. NM_053158.3 → NP_444388.2  large ribosomal subunit protein uL1m isoform 1

      See identical proteins and their annotated locations for NP_444388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132243, AI462572, AK142249
      Consensus CDS
      CCDS19449.1
      UniProtKB/Swiss-Prot
      Q3UQP5, Q8K351, Q99N96, Q9CWW4
      Conserved Domains (1) summary
      cl00322
      Location:102 → 244
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      96357357..96414586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535292.2 → XP_006535355.1  large ribosomal subunit protein uL1m isoform X1

      See identical proteins and their annotated locations for XP_006535355.1

      UniProtKB/Swiss-Prot
      Q3UQP5, Q8K351, Q99N96, Q9CWW4
      Related
      ENSMUSP00000112977.2, ENSMUST00000117766.8
      Conserved Domains (1) summary
      cl00322
      Location:102 → 244
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    2. XM_011249596.3 → XP_011247898.1  large ribosomal subunit protein uL1m isoform X2

      Conserved Domains (1) summary
      cl00322
      Location:20 → 162
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    RNA

    1. XR_004942590.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N96.2 GenPept UniProtKB/Swiss-Prot:Q99N96

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