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    Adad2 adenosine deaminase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 75773, updated on 12-May-2024

    Summary

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    Official Symbol
    Adad2provided by MGI
    Official Full Name
    adenosine deaminase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1923023
    See related
    Ensembl:ENSMUSG00000024266 AllianceGenome:MGI:1923023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930403J07Rik
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be active in cytoplasm and nucleolus. Is expressed in central nervous system; olfactory epithelium; and testis. Orthologous to human ADAD2 (adenosine deaminase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 24.1) and duodenum adult (RPKM 1.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 68.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120339449..120343665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119612710..119616926)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene potassium voltage-gated channel, subfamily G, member 4 Neighboring gene predicted gene, 46055 Neighboring gene predicted gene, 46054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis. Xiong M, et al. J Cell Biol, 2023 May 1. PMID 36930220, Free PMC Article
    2. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Lu Y, et al. Andrology, 2023 May. PMID 36698249, Free PMC Article
    3. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility. Snyder E, et al. Sci Rep, 2020 Jul 14. PMID 32665638, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
      Title: Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
    2. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.
      Title: ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.
    3. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
      Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine deaminase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029428.2 → NP_083704.1  adenosine deaminase domain-containing protein 2

      See identical proteins and their annotated locations for NP_083704.1

      Status: VALIDATED

      Source sequence(s)
      AC104882
      Consensus CDS
      CCDS52683.1
      UniProtKB/Swiss-Prot
      B2RQL4, Q9D5P4
      Related
      ENSMUSP00000095964.3, ENSMUST00000098361.4
      Conserved Domains (2) summary
      cd00048
      Location:101 → 157
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02137
      Location:239 → 554
      A_deamin; Adenosine-deaminase (editase) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120339449..120343665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531467.2 → XP_006531530.1  adenosine deaminase domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      cl00054
      Location:90 → 157
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl02661
      Location:239 → 272
      A_deamin; Adenosine-deaminase (editase) domain

    2. XM_006531464.2 → XP_006531527.1  adenosine deaminase domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      cl00054
      Location:90 → 157
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl02661
      Location:239 → 488
      A_deamin; Adenosine-deaminase (editase) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5P4.2 GenPept UniProtKB/Swiss-Prot:Q9D5P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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