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    HTR1D 5-hydroxytryptamine receptor 1D [ Homo sapiens (human) ]

    Gene ID: 3352, updated on 11-Apr-2024

    Summary

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    Official Symbol
    HTR1Dprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Dprovided by HGNC
    Primary source
    HGNC:HGNC:5289
    See related
    Ensembl:ENSG00000179546 MIM:182133; AllianceGenome:HGNC:5289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTRL; RDC4; HT1DA; 5-HT1D; HTR1DA
    Summary
    Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See HTR1D in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23191895..23217502, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23017572..23043163, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23518388..23543995, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine zipper protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494055-23494586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494587-23495118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 357 Neighboring gene RNA, U6 small nuclear 514, pseudogene Neighboring gene RNA, U6 small nuclear 135, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 407 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:23515051-23516250 Neighboring gene MPRA-validated peak115 silencer Neighboring gene MPRA-validated peak116 silencer Neighboring gene Sharpr-MPRA regulatory region 9970 Neighboring gene ribosomal protein L29 pseudogene 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23589770-23590604 Neighboring gene long intergenic non-protein coding RNA 1355

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway. Wu W, et al. Int J Biol Sci, 2022. PMID 35813473, Free PMC Article
    2. Knockdown and inhibition of hydroxytryptamine receptor 1D suppress proliferation and migration of gastric cancer cells. Jin X, et al. Biochem Biophys Res Commun, 2022 Sep 10. PMID 35785570
    3. Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus. Thompson MD, et al. Neuroreport, 2012 Jan 4. PMID 22107845
    4. Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences. Goswami DB, et al. J Neurochem, 2010 Jan. PMID 19878438, Free PMC Article
    5. Cell adhesion modulates 5-HT(1D) and P2Y receptor signal trafficking differentially in LTK-8 cells. Amber-Cicek F, et al. Eur J Pharmacol, 2008 Aug 20. PMID 18582865

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown and inhibition of hydroxytryptamine receptor 1D suppress proliferation and migration of gastric cancer cells.
      Title: Knockdown and inhibition of hydroxytryptamine receptor 1D suppress proliferation and migration of gastric cancer cells.
    2. HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway.
      Title: HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway.
    3. significantly promotes hepatocellular carcinoma (HCC) proliferation, epithelial-mesenchymal transition, and metastasis; elevated expression level predicts poor overall survival and high recurrence probability in HCC patients
      Title: 5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma Progression Through FoxO6 in AKT-Dependent and Independent Manners.
    4. Data show that 5-hydroxytryptamine receptor (5-HT1DR) played an important role in cell invasion via Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway.
      Title: 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway.
    5. results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non- diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D
      Title: Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
    6. Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
      Title: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
    7. 5-HT1B- and 5-HT1D-mediated signaling play an important role in the regulation of the proliferative and invasive phenotype of pancreatic cancer cells.
      Title: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
    8. study identified the presence of genetic association at chromosome 1p36 with migraine with aura (P=0.045, Bonferroni corrected): the locus encoding the 5HT(1D) receptor gene
      Title: Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
    10. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestine smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1D
    Names
    5-HT-1D
    5-HT-1D-alpha
    5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
    serotonin 1D alpha receptor
    serotonin receptor 1D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000864.5 → NP_000855.1  5-hydroxytryptamine receptor 1D

      See identical proteins and their annotated locations for NP_000855.1

      Status: VALIDATED

      Source sequence(s)
      AL049576, AL353585
      Consensus CDS
      CCDS231.1
      UniProtKB/Swiss-Prot
      P28221
      Related
      ENSP00000363748.1, ENST00000374619.2
      Conserved Domains (1) summary
      cd15333
      Location:35 → 367
      7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23191895..23217502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23017572..23043163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28221.1 GenPept UniProtKB/Swiss-Prot:P28221

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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