Aoc1l3 amine oxidase copper containing 1-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aoc1l3provided by MGI
Official Full Name: amine oxidase copper containing 1-like 3provided by MGI
Primary source: MGI:MGI:2682321
See related: Ensembl:ENSMUSG00000039215 AllianceGenome:MGI:2682321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Svs1; 9530003A11
Summary: Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Is expressed in skeleton. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 1.5), subcutaneous fat pad adult (RPKM 0.2) and 1 other tissue See more
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Genomic context

Location:: 6 B2.3; 6 23.82 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48963795..48968659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48986861..48991725)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The androgen-dependent SVS I is exclusively expressed in the luminal epithelium of seminal vesicle; Gln232 and Gln254 are the major TG4-reactive residues on SVS I and and TG4 is much stronger than TG2 to cross-link the glutamine residues in SVS I.
Title: Identification of the major TG4 cross-linking sites in the androgen-dependent SVS I exclusively expressed in mouse seminal vesicle.
SVS1 seems to be found only in rodents and does not exist in humans
Title: Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidases.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables diamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables histamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: seminal vesicle-secreted protein I

Names: seminal vesicle secretion 1; seminal vesicle secretory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172888.3 → NP_766476.2 seminal vesicle-secreted protein I precursor

See identical proteins and their annotated locations for NP_766476.2

Status: VALIDATED

Source sequence(s)

AC159547, AK035222, BB873086

Consensus CDS

CCDS20121.1

UniProtKB/TrEMBL

Q6WIZ7, Q8BZI2

Related

ENSMUSP00000045221.5, ENSMUST00000037696.6

Conserved Domains (4) summary

pfam01179
Location:409 → 805

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:44 → 130

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 246

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

pfam15240
Location:264 → 416

Pro-rich; Proline-rich