Anxa3 annexin A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa3provided by MGI
Official Full Name: annexin A3provided by MGI
Primary source: MGI:MGI:1201378
See related: Ensembl:ENSMUSG00000029484 AllianceGenome:MGI:1201378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anx3
Summary: Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and phospholipase A2 inhibitor activity. Predicted to be involved in several processes, including neutrophil degranulation; positive regulation of endothelial cell migration; and regulation of nucleobase-containing compound metabolic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including Meckel's cartilage; brain meninges; cardiovascular system; hindlimb interdigital region; and rectum. Orthologous to human ANXA3 (annexin A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 32.8), placenta adult (RPKM 31.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.29 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (96941257..96993825)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (96793385..96845968)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury.
Title: ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury.
Annexin A3 accelerates osteoclast differentiation by promoting the level of RANK and TRAF6.
Title: Annexin A3 accelerates osteoclast differentiation by promoting the level of RANK and TRAF6.
miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway.
Title: miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway.
Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1alpha/vascular endothelial growth factor signaling pathway.
Title: Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1α/vascular endothelial growth factor signaling pathway.
Annexin A3 regulates early blood vessel formation.
Title: Annexin A3 Regulates Early Blood Vessel Formation.
data suggest that annexin A3 is a negative regulator of adipocyte differentiation
Title: Annexin A3 as a negative regulator of adipocyte differentiation.
AnxA3 is not only endogenously expressed in mouse cortical neurons but more importantly, it is transcriptionally up-regulated with onset of lactacystin-mediated death in murine primary cortical neurons.
Title: Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A3

Names: 35-alpha calcimedin; PAP-III; annexin III; annexin-3; lipocortin III; placental anticoagulant protein III

NP_001407036.1

EC 3.1.4.43

NP_001407037.1

EC 3.1.4.43

NP_001407038.1

EC 3.1.4.43

NP_038498.2

EC 3.1.4.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.