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    SCRG1 stimulator of chondrogenesis 1 [ Homo sapiens (human) ]

    Gene ID: 11341, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SCRG1provided by HGNC
    Official Full Name
    stimulator of chondrogenesis 1provided by HGNC
    Primary source
    HGNC:HGNC:17036
    See related
    Ensembl:ENSG00000164106 MIM:603163; AllianceGenome:HGNC:17036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCRG-1; lincSCRG1
    Summary
    Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in brain (RPKM 46.0), testis (RPKM 30.3) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q34.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173384701..173519144, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176724109..176858933, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174305852..174440295, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SAP30 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:174292649-174293212 Neighboring gene uncharacterized LOC112268474 Neighboring gene Sin3A associated protein 30 Neighboring gene 60S ribosomal protein L38-like Neighboring gene NANOG hESC enhancer GRCh37_chr4:174356204-174356706 Neighboring gene ribosomal protein L5 pseudogene 11 Neighboring gene VISTA enhancer hs2501 Neighboring gene RNA, U6 small nuclear 1096, pseudogene Neighboring gene uncharacterized LOC112267917 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174410607-174411181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22160 Neighboring gene uncharacterized LOC101928409 Neighboring gene uncharacterized LOC124900815 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:174439311-174440510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:174445895-174446436 Neighboring gene uncharacterized LOC124900816 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174457885-174458386 Neighboring gene HAND2 antisense RNA 1 Neighboring gene heart and neural crest derivatives expressed 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation. Liu G, et al. Front Immunol, 2022. PMID 35720295, Free PMC Article
    2. A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. Ochi K, et al. Osteoarthritis Cartilage, 2006 Jan. PMID 16188469
    3. linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin. Wu JC, et al. FASEB J, 2019 Feb. PMID 30226813
    4. Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro. Yuan R, et al. Molecules, 2023 Jan 28. PMID 36770940, Free PMC Article
    5. Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects. Cohen ASA, et al. Am J Med Genet A, 2020 May. PMID 32134193

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.
      Title: Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.
    2. Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation.
      Title: Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation.
    3. Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects.
      Title: Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects.
    4. High lncRNA in SCRG1 gene expression is associated with liver fibrosis.
      Title: linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin.
    5. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
      Title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
    6. Aomatsu et al. identified a novel SCRG1/BST1 (CD157) ligand-receptor combination that maintains human mesenchymal stem cells expressions of stem cell markers Oct-4 and CD271 (LNGFR), as well as self-renewal, migration, and osteogenic differentiation potentials during ex vivo expansion.
      Title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26468

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuron projection terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scrapie-responsive protein 1
    Names
    scrapie responsive gene 1
    scrapie-responsive gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329597.2 → NP_001316526.1  scrapie-responsive protein 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC093849, AC097534
      Consensus CDS
      CCDS3818.1
      UniProtKB/Swiss-Prot
      O75711
      UniProtKB/TrEMBL
      D3DP39, D6RD99, Q6FGG5
      Conserved Domains (1) summary
      pfam15224
      Location:22 → 97
      SCRG1; Scrapie-responsive protein 1

    2. NM_007281.4 → NP_009212.1  scrapie-responsive protein 1 precursor

      See identical proteins and their annotated locations for NP_009212.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC097534, AJ224677
      Consensus CDS
      CCDS3818.1
      UniProtKB/Swiss-Prot
      O75711
      UniProtKB/TrEMBL
      D3DP39, D6RD99, Q6FGG5
      Related
      ENSP00000296506.2, ENST00000296506.8
      Conserved Domains (1) summary
      pfam15224
      Location:22 → 97
      SCRG1; Scrapie-responsive protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      173384701..173519144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449563.1 → XP_047305519.1  scrapie-responsive protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O75711
      UniProtKB/TrEMBL
      D3DP39, Q6FGG5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      176724109..176858933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348845.1 → XP_054204820.1  scrapie-responsive protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O75711
      UniProtKB/TrEMBL
      D3DP39, Q6FGG5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75711.1 GenPept UniProtKB/Swiss-Prot:O75711

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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