Pcdh8 protocadherin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdh8provided by MGI
Official Full Name: protocadherin 8provided by MGI
Primary source: MGI:MGI:1306800
See related: Ensembl:ENSMUSG00000036422 AllianceGenome:MGI:1306800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Papc; 1700080P15Rik
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
Expression: Biased expression in whole brain E14.5 (RPKM 19.8), CNS E18 (RPKM 18.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 42.76 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (80004224..80008752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (79766772..79771312, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice.
Title: Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice.
in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin
Title: PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion.
miR-429 suppresses the expression of Pcdh8 mRNA and protein.
Title: MicroRNA-429 functions as a regulator of epithelial-mesenchymal transition by targeting Pcdh8 during murine embryo implantation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

42.MMHAP38FLF6.seq (e-PCR)
- UniSTS:124459

Pcdh8 (e-PCR), detects polymorphism
- UniSTS:525992

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protocadherin-8

Names: arcadlin; paraxial protocadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042726.4 → NP_001036191.1 protocadherin-8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC151973

Consensus CDS

CCDS79349.1

UniProtKB/Swiss-Prot

Q7TSK3

Related

ENSMUSP00000141417.2, ENSMUST00000195355.2

Conserved Domains (2) summary

cd11304
Location:501 → 605

Cadherin_repeat; Cadherin tandem repeat domain

cl09101
Location:31 → 109

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_021543.5 → NP_067518.2 protocadherin-8 isoform 1 precursor

See identical proteins and their annotated locations for NP_067518.2

Status: VALIDATED

Source sequence(s)

AC151973

Consensus CDS

CCDS27303.1

UniProtKB/Swiss-Prot

Q05BD0, Q7TSK3, Q8C824, Q9JKP3

Related

ENSMUSP00000045333.6, ENSMUST00000039568.11

Conserved Domains (2) summary

cd11304
Location:501 → 605

Cadherin_repeat; Cadherin tandem repeat domain

cl09101
Location:31 → 109

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus