Immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Immp2lprovided by MGI
Official Full Name: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:2135611
See related: Ensembl:ENSMUSG00000056899 AllianceGenome:MGI:2135611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP2; Tg(HLA-A/H2-D)2Enge
Summary: Enables peptidase activity. Acts upstream of or within several processes, including cerebellum vasculature development; gamete generation; and mitochondrion organization. Located in mitochondrion. Part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 4.9), liver adult (RPKM 3.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B1; 12 18.69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (41074060..42002371)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (41024061..41955588)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase.
Title: Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase.
Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
Title: Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.
Title: Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.
Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.
Title: Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.
Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
Title: Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Title: LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
[IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].
Title: [IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].
The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/beta-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
Title: The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
IMP2-deficient muscle exhibits reduced fatty acid oxidation, due to a reduced abundance of mRNA of peroxisome proliferator-activated receptor alpha (PPARalpha), an IMP2 client, and PPARalpha protein. IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose.
Title: IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.
Data indicates that overexpression of IMP2 alters the regulatory capacity of many miRNAs and conclude that IMP2 competes with miRNAs for binding sites on thousands of transcripts. As a result, data implicates that overexpression of IMP2 has distinct effects to the regulatory capacity of miRNAs with yet unknown consequences for translational efficiency.
Title: Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (2) 1 citation
Endonuclease-mediated (4)
Chemically induced (ENU) (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493077

NoName (e-PCR)
- UniSTS:224799

D0M12Mit2 (e-PCR)
- UniSTS:126755

D12Mit2 (e-PCR), detects polymorphism
- UniSTS:126755

D12Mit244 (e-PCR), detects polymorphism
- UniSTS:126800

AI853880 (e-PCR)
- UniSTS:164495

D12Mit62 (e-PCR), detects polymorphism
- UniSTS:126882

48.MMHAP97FRH12.seq (e-PCR)
- UniSTS:160202

D12Mit125 (e-PCR), detects polymorphism
- UniSTS:126679

Lrrn3 (e-PCR), detects polymorphism
- UniSTS:525562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial respiratory chain complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	ISA Inferred from Sequence Alignment more info	PubMed
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein processing involved in protein targeting to mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal peptide processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within superoxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISA Inferred from Sequence Alignment more info	PubMed
part_of mitochondrial inner membrane peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial inner membrane peptidase complex	IGI Inferred from Genetic Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial inner membrane protease subunit 2

Names: AAD mice; IMP2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053122.5 → NP_444352.2 mitochondrial inner membrane protease subunit 2

See identical proteins and their annotated locations for NP_444352.2

Status: VALIDATED

Source sequence(s)

AC123620, AC124826, AC153793, AC240395

Consensus CDS

CCDS83961.1

UniProtKB/Swiss-Prot

Q3TTI2, Q8BPT6, Q925F6

Related

ENSMUSP00000118779.2, ENSMUST00000132121.8

Conserved Domains (2) summary

cd06530
Location:36 → 146

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

TIGR02227
Location:33 → 152

sigpep_I_bact; signal peptidase I, bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

41074060..42002371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247004.2 → XP_030102864.1 mitochondrial inner membrane protease subunit 2 isoform X3

Conserved Domains (1) summary

cd06530
Location:36 → 77

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_036157690.1 → XP_036013583.1 mitochondrial inner membrane protease subunit 2 isoform X4

Conserved Domains (1) summary

cd06530
Location:36 → 77

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_017315261.3 → XP_017170750.1 mitochondrial inner membrane protease subunit 2 isoform X1

Conserved Domains (1) summary

TIGR02227
Location:53 → 125

sigpep_I_bact; signal peptidase I, bacterial type
XM_017315262.2 → XP_017170751.1 mitochondrial inner membrane protease subunit 2 isoform X2

Conserved Domains (1) summary

TIGR02227
Location:73 → 117

sigpep_I_bact; signal peptidase I, bacterial type