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    Ninj2 ninjurin 2 [ Mus musculus (house mouse) ]

    Gene ID: 29862, updated on 2-May-2024

    Summary

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    Official Symbol
    Ninj2provided by MGI
    Official Full Name
    ninjurin 2provided by MGI
    Primary source
    MGI:MGI:1352751
    See related
    Ensembl:ENSMUSG00000041377 AllianceGenome:MGI:1352751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human NINJ2 (ninjurin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 1.9), cerebellum adult (RPKM 1.1) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F1; 6 56.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120070315..120177300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120093380..120200531)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_17155 Neighboring gene STARR-seq mESC enhancer starr_17156 Neighboring gene STARR-positive B cell enhancer mm9_chr6:119988697-119988998 Neighboring gene STARR-positive B cell enhancer ABC_E1708 Neighboring gene microRNA 706 Neighboring gene STARR-positive B cell enhancer ABC_E8832 Neighboring gene STARR-positive B cell enhancer ABC_E11333 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120061967-120062268 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120062467-120062768 Neighboring gene STARR-seq mESC enhancer starr_17160 Neighboring gene STARR-positive B cell enhancer ABC_E2801 Neighboring gene STARR-positive B cell enhancer ABC_E2802 Neighboring gene STARR-positive B cell enhancer ABC_E10405 Neighboring gene predicted gene, 25327 Neighboring gene STARR-seq mESC enhancer starr_17164 Neighboring gene STARR-positive B cell enhancer ABC_E6477 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3 Neighboring gene STARR-seq mESC enhancer starr_17178 Neighboring gene STARR-seq mESC enhancer starr_17179 Neighboring gene STARR-seq mESC enhancer starr_17181 Neighboring gene STARR-positive B cell enhancer ABC_E3675 Neighboring gene STARR-positive B cell enhancer ABC_E11334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120314296-120314483 Neighboring gene coiled-coil domain containing 77 Neighboring gene lysine demethylase 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway. Wang Y, et al. Metabolism, 2023 Mar. PMID 36549436
    2. NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling. Peng H, et al. Obesity (Silver Spring), 2023 Jan. PMID 36504350
    3. Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. Sun Y, et al. Theranostics, 2022. PMID 36438492, Free PMC Article
    4. Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors. Sun Y, et al. Adv Sci (Weinh), 2022 Jan. PMID 34787377, Free PMC Article
    5. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. Araki T, et al. J Neurosci, 2000 Jan 1. PMID 10627596, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis.
      Title: Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis.
    2. Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway.
      Title: Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway.
    3. NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling.
      Title: NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling.
    4. Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.
      Title: Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.
    5. Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
      Title: Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143502

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ninjurin-2
    Names
    nerve injury-induced protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347432.2 → NP_001334361.1  ninjurin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156951
      Consensus CDS
      CCDS85148.1
      UniProtKB/TrEMBL
      F8WIJ3
      Related
      ENSMUSP00000046306.6, ENSMUST00000035244.6

    2. NM_016718.3 → NP_057927.1  ninjurin-2 isoform 1

      See identical proteins and their annotated locations for NP_057927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC113092, AC156951
      Consensus CDS
      CCDS39612.1
      UniProtKB/Swiss-Prot
      Q9JL89
      UniProtKB/TrEMBL
      Q3TQA7
      Related
      ENSMUSP00000108331.3, ENSMUST00000112711.9
      Conserved Domains (1) summary
      pfam04923
      Location:26 → 126
      Ninjurin; Ninjurin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120070315..120177300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166209.1 → XP_036022102.1  ninjurin-2 isoform X1

      Conserved Domains (1) summary
      pfam04923
      Location:11 → 111
      Ninjurin

    2. XM_006506224.5 → XP_006506287.1  ninjurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006506287.1

      Conserved Domains (1) summary
      pfam04923
      Location:11 → 111
      Ninjurin

    3. XM_006506223.5 → XP_006506286.1  ninjurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006506286.1

      Conserved Domains (1) summary
      pfam04923
      Location:11 → 111
      Ninjurin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL89.1 GenPept UniProtKB/Swiss-Prot:Q9JL89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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