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    Pcdhb15 protocadherin beta 15 [ Mus musculus (house mouse) ]

    Gene ID: 93886, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcdhb15provided by MGI
    Official Full Name
    protocadherin beta 15provided by MGI
    Primary source
    MGI:MGI:2136750
    See related
    Ensembl:ENSMUSG00000047033 AllianceGenome:MGI:2136750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcdhb7; PcdhbO
    Summary
    Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Is expressed in brain; metanephros; and placenta. Orthologous to human PCDHB7 (protocadherin beta 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    18 B3; 18 19.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37606599..37609393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37473546..37476340)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 13 Neighboring gene protocadherin beta 14 Neighboring gene protocadherin beta 16 Neighboring gene protocadherin beta 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
    2. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. Dallosso AR, et al. PLoS Genet, 2009 Nov. PMID 19956686, Free PMC Article
    3. Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development. Alvarez-Saavedra M, et al. Front Mol Neurosci, 2019. PMID 31680852, Free PMC Article
    4. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
    5. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin beta-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053140.3 → NP_444370.1  protocadherin beta-7

      See identical proteins and their annotated locations for NP_444370.1

      Status: VALIDATED

      Source sequence(s)
      AK038663
      Consensus CDS
      CCDS29181.1
      UniProtKB/TrEMBL
      Q6NZD9, Q91Y04
      Related
      ENSMUSP00000059598.2, ENSMUST00000050034.3
      Conserved Domains (3) summary
      cd11304
      Location:247 → 343
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:30 → 111
      Cadherin_2; Cadherin-like
      pfam16492
      Location:686 → 769
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37606599..37609393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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