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    Gpbp1 GC-rich promoter binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 73274, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gpbp1provided by MGI
    Official Full Name
    GC-rich promoter binding protein 1provided by MGI
    Primary source
    MGI:MGI:1920524
    See related
    Ensembl:ENSMUSG00000032745 AllianceGenome:MGI:1920524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpbp; mGPBP; 1700034P14Rik; D230035M11Rik
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human GPBP1 (GC-rich promoter binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 28.7), CNS E11.5 (RPKM 24.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D2.2; 13 63.23 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111562214..111626658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111425680..111490128, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene actin, beta-like 2 Neighboring gene electron transfer flavoprotein subunit alpha, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2421 Neighboring gene STARR-positive B cell enhancer ABC_E1468 Neighboring gene STARR-seq mESC enhancer starr_35655 Neighboring gene STARR-seq mESC enhancer starr_35658 Neighboring gene predicted gene 15290 Neighboring gene STARR-seq mESC enhancer starr_35661 Neighboring gene STARR-seq mESC enhancer starr_35662 Neighboring gene predicted gene 15286 Neighboring gene STARR-positive B cell enhancer ABC_E10815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu LC, et al. Mol Cell Biol, 2003 Dec. PMID 14612417, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. binds specifically to the adenosine deaminase gene promoter
      Title: The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vasculin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122963.3 → NP_001116435.1  vasculin isoform 1

      See identical proteins and their annotated locations for NP_001116435.1

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Consensus CDS
      CCDS49362.1
      UniProtKB/Swiss-Prot
      Q3TQR2, Q3TSN7, Q6NXH3, Q6TYE7, Q8C498, Q8R252
      Related
      ENSMUSP00000088777.5, ENSMUST00000091236.11
      Conserved Domains (1) summary
      pfam15337
      Location:377 → 457
      Vasculin; Vascular protein family Vasculin-like 1

    2. NM_001361923.2 → NP_001348852.1  vasculin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Conserved Domains (1) summary
      pfam15337
      Location:273 → 352
      Vasculin; Vascular protein family Vasculin-like 1

    3. NM_001361924.2 → NP_001348853.1  vasculin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Conserved Domains (1) summary
      pfam15337
      Location:252 → 331
      Vasculin; Vascular protein family Vasculin-like 1

    4. NM_001361925.2 → NP_001348854.1  vasculin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Conserved Domains (1) summary
      pfam15337
      Location:207 → 286
      Vasculin; Vascular protein family Vasculin-like 1

    5. NM_001361926.2 → NP_001348855.1  vasculin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Conserved Domains (1) summary
      pfam15337
      Location:207 → 286
      Vasculin; Vascular protein family Vasculin-like 1

    6. NM_028487.6 → NP_082763.3  vasculin isoform 2

      See identical proteins and their annotated locations for NP_082763.3

      Status: VALIDATED

      Source sequence(s)
      AC118475
      Consensus CDS
      CCDS26769.1
      UniProtKB/Swiss-Prot
      Q6NXH3
      Related
      ENSMUSP00000048240.8, ENSMUST00000047627.14
      Conserved Domains (1) summary
      pfam15337
      Location:397 → 477
      Vasculin; Vascular protein family Vasculin-like 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      111562214..111626658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247436.2 → XP_030103296.1  vasculin isoform X3

      Conserved Domains (1) summary
      pfam15337
      Location:273 → 352
      Vasculin; Vascular protein family Vasculin-like 1

    2. XM_030247435.2 → XP_030103295.1  vasculin isoform X2

      UniProtKB/Swiss-Prot
      Q3TQR2, Q3TSN7, Q6NXH3, Q6TYE7, Q8C498, Q8R252
      Conserved Domains (1) summary
      pfam15337
      Location:377 → 457
      Vasculin; Vascular protein family Vasculin-like 1

    3. XM_006517772.2 → XP_006517835.1  vasculin isoform X1

      See identical proteins and their annotated locations for XP_006517835.1

      UniProtKB/Swiss-Prot
      Q6NXH3
      Conserved Domains (1) summary
      pfam15337
      Location:397 → 477
      Vasculin; Vascular protein family Vasculin-like 1

    4. XM_036158193.1 → XP_036014086.1  vasculin isoform X3

      Conserved Domains (1) summary
      pfam15337
      Location:273 → 352
      Vasculin; Vascular protein family Vasculin-like 1

    5. XM_036158194.1 → XP_036014087.1  vasculin isoform X4

      Conserved Domains (1) summary
      pfam15337
      Location:207 → 286
      Vasculin; Vascular protein family Vasculin-like 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXH3.1 GenPept UniProtKB/Swiss-Prot:Q6NXH3

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