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    Naxd NAD(P)HX dehydratase [ Mus musculus (house mouse) ]

    Gene ID: 69225, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Naxdprovided by MGI
    Official Full Name
    NAD(P)HX dehydrataseprovided by MGI
    Primary source
    MGI:MGI:1913353
    See related
    Ensembl:ENSMUSG00000031505 AllianceGenome:MGI:1913353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Carkd; 0710008K08Rik; 2810407E01Rik
    Summary
    Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Located in cytosol; endoplasmic reticulum; and mitochondrion. Is expressed in metanephros. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 54.6), lung adult (RPKM 48.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11547506..11563287)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11497506..11513287)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 2 Neighboring gene predicted gene 15419 Neighboring gene STARR-positive B cell enhancer ABC_E8227 Neighboring gene RIKEN cDNA E230013L22 gene Neighboring gene RAB20, member RAS oncogene family Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Marbaix AY, et al. Biochem J, 2014 May 15. PMID 24611804
    2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
    3. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 0710008K08Rik, 2810407E01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metabolite repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Names
    ATP-dependent NAD(P)HX dehydratase
    carbohydrate kinase domain containing
    carbohydrate kinase domain-containing protein
    NP_001177286.1
    NP_001280590.1
    NP_001389565.1
    NP_081271.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190357.1 → NP_001177286.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2

      See identical proteins and their annotated locations for NP_001177286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK012456, BC030080, BY270677
      Consensus CDS
      CCDS57604.1
      UniProtKB/Swiss-Prot
      Q9CQX9, Q9CZ42, Q9D7G7, Q9DC93
      UniProtKB/TrEMBL
      J3QMM7
      Related
      ENSMUSP00000136363.2, ENSMUST00000177955.8
      Conserved Domains (1) summary
      cd01171
      Location:49 → 316
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    2. NM_001293661.1 → NP_001280590.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame exon in the 5' UTR and 5' coding region and lacks an alternate coding exon in the 3' end compared to variant 1. This results in a shorter protein (isoform 2) with distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BC030080, BY270677, DV045296
      Consensus CDS
      CCDS80857.1
      UniProtKB/TrEMBL
      J3QN06
      Related
      ENSMUSP00000136535.2, ENSMUST00000178721.2
      Conserved Domains (1) summary
      cd01171
      Location:49 → 237
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    3. NM_001402636.1 → NP_001389565.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124475

    4. NM_026995.4 → NP_081271.2  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124475, AK013028, BC030080, BY254286
      Consensus CDS
      CCDS22096.2
      UniProtKB/Swiss-Prot
      Q9CQX9, Q9CZ42, Q9D7G7, Q9DC93
      UniProtKB/TrEMBL
      K3W4M4
      Related
      ENSMUSP00000033901.5, ENSMUST00000033901.11
      Conserved Domains (1) summary
      cd01171
      Location:87 → 354
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      11547506..11563287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ42.1 GenPept UniProtKB/Swiss-Prot:Q9CZ42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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